Objective
A mechano-regulation computational model for musculoskeletal tissue differentiation and growth is desired to develop strategies for tissue engineering and regenerative therapies of bone and cartilage. The goal of this project is to develop and corroborate a computational adaptive model to longer-term growth of cartilage and bone in a bioreactor. Previous studies on fracture healing have demonstrated that mechanoregulation theories based on deviatoric strain and fluid flow was most promising.
This theory was then combined with mechanistic descriptions of cellular processes to improve its corroboration with bone healing as observed in vivo. In this project, the fracture healing adaptive model will be modified in order to simulate longer term in vitro experiments using a pre-existing bioreactor that was developed to test the potential of the mechanoregulation theory. First of all, the empiric constants of the model will be determined from experimental and literature data. Then, data from long term experiments w ill be generated in parallel projects and will be available for further development of cell process modelling.
Finally, the full adaptive tissue differentiation and regeneration models will be corroborated by comparing its a priori simulations with that of results from long term in vitro experiments with different boundary conditions (data generated in parallel projects). As this may be time consuming, if many cell processes are determined to be significant in the previous studies, the processes will be evaluated one by one starting with the process of highest significance until satisfactory corroborations of the full adaptive model are achieved.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- engineering and technology environmental biotechnology bioremediation bioreactors
- natural sciences chemical sciences inorganic chemistry alkaline earth metals
- medical and health sciences medical biotechnology tissue engineering
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2005-MOBILITY-5
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
DAVOS PLATZ
Switzerland
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.