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Concerted Safety & Efficiency Evaluation of Retroviral Transgenesis in Gene Therapy of Inherited Diseases

Objective

CONSERT will integrate leading European activities for a structured implementation of novel therapies using genetically enhanced postnatal stem cells, with focus on the treatment of monogenic immunodeficiencies, hemoglobinopathies, anemias and storage disorders.
CONSERT will develop and evaluate methods for genetic stem cell modification with wide implications for many other disorders including viral infection and cancer. A central theme of the project is an unbiased safety and efficiency evaluation of the key technology used in the genetic modifications of replicating somatic cells: retroviral vector-mediated transgenesis. This is only possible through concerted multi-center studies. Lenti-, spuma- and gamma-retroviral vectors will be tailor-made for target disorders and tested for potency and safety in preclinical disease models. Designed with a translational aim, basic studies in stem cell biology and selectable marker technology will complement this research. A most important aspect of CONSERT is the molecular and clinical monitoring of currently active and successful clinical trials of genetic therapies. This will create a paradigmatic data-mining activity to obtain insights into crucial issues of clonal kinetics of gene-modified cells in vivo. Molecular studies in precise cell systems and animal models will provide the mechanistic understanding of transgene-host interactions. This project will generate the basis for technology development and promote patient safety. Translational dissemination of know-how from academia to industry will create a network of cell processing manufacturers with large economic potential, and prepare future clinical studies with improved predictability. Supervised by a proactive ethical project, CONSERT will stimulate a competitive and complementary evolution of biomedical academia, clinics, innovative health service providers, and associated training opportunities.

Call for proposal

FP6-2003-LIFESCIHEALTH-I
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Funding Scheme

IP - Integrated Project

Coordinator

ERASMUS UNIVERSITY MEDICAL CENTER ROTTERDAM
Address
Dr Molewaterplein 50
Rotterdam
Netherlands

Participants (23)

MEDIZINISCHE HOCHSCHULE HANNOVER
Germany
Address
Carl-neuberg-str. 1
Hannover
EUROPAEISCHES INSTITUT FUR FORSCHUNG UND ENTWICKLUNG VON TRANSPLANTATIONSSTRATEGIE AG
Germany
Address
Vollmersbachstrasse 66
Idar-oberstein
INSTITUT FUR WISSENSCHAFT UND ETHIK E.V.
Germany
Address
Niebuhrstr. 51
Bonn
GATC BIOTECH AG
Germany
Address
Jakob-stadler-platz 7
Konstanz
BANC DE SANG I TEIXITS
Spain
Address
Passeig Vall D'hebron 119-129
Barcelona
CENTRO DE INVESTIGACIONES ENERGETICAS MEDIAMBIENTALES Y TECHNOLOGICAS
Spain
Address
Avenida Complutense 22
Madrid
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICINALE
France
Address
101 Rue De Tolbiac
Paris
GENETHON
France
Address
1 Bis Rue De L' Internationale
Evry
GENOMINING
France
Address
4 Rue Rene Barthelemy
Montrouge
NATIONAL AND KAPODISTRIAN UNIVERSITY OF ATHENS
Greece
Address
75 Micras Asias Street
Athens
MOLECULAR MEDICINE S.P.A.
Italy
Address
Via Olgettina 58
Milan
FONDAZIONE CENTRO SAN RAFFAELE DEL MONTE TABOR
Italy
Address
Via Olgettina 60
Milan
UNIVERSITA VITA-SALUTE SAN RAFFAELE
Italy
Address
Via Olgettina 58
Milan
LOUISE VAN DEN BOS SCIENCE & TECHNOLOGY TRANSFER
Netherlands
Address
Hoflaan 120
Rotterdam
LUNDS UNIVERSITET
Sweden
Address
Paradisgatan 5
Lund
UNIVERSITY COLLEGE LONDON
United Kingdom
Address
Gower Street
London
THE VICTORIA UNIVERSITY OF MANCHESTER
United Kingdom
Address
Oxford Road
Manchester
FOUNDATION OF BIOMEDICAL RESEARCH
Greece
Address
6 Christou Lada Str.
Athens
GEORG SPEYER HAUS
Germany
Address
Paul-ehrlich-strasse 42-44
Frankfurt Am Main
EUROPEAN GENETIC ALLIANCES' NETWORK
Belgium
Address
Avenue Louise 287
Brussels
DEUTSCHES KREBSFORSCHUNGSZENTRUM
Germany
Address
Im Neuenheimer Feld 280
Heidelberg
ECOLE POLYTECHNIQUE FÉDÉRALE DE LAUSANNE
Switzerland
Address

Lausanne
UNIVERSITÄTSKLINIKUM FREIBURG
Germany
Address
Hugstetter Str. 49
Freiburg