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Neurobiology and Treatment of Adolescent Female Conduct Disorder: The Central Role of Emotion Processing

Objective

Conduct Disorder (CD) and Oppositional Defiant Disorder with symptoms of Conduct Disorder (which is included among the abbreviation “CD” throughout the proposal) has a highly negative impact for the affected individual as well as for families and society. Although the number of females exhibiting serious aggressive behaviours is growing, the majority of studies on aetiology and treatment of CD have focused on male subjects only, despite strong evidence for a differential neurobiological basis of female CD. The key aims of the FemNAT-CD consortium are to identify biomarkers and to study disease mechanisms from pre- to postpubertal female CD as well as new psychological and pharmacological treatment options for female adolescent CD targeting emotion processing abilities. With the present proposal, we aim at clarifying the phenomenology and neurobiology of female CD from pre-puberty to post-puberty. We will study the role of genetic and environmental risk factors on female CD, related psychopathology, brain structure and function, HPA axis and autonomic nervous system (ANS) disturbance to elicit CD specific endophenotypes and its biomarkers. We will describe the clinical, neuronal and neurocognitive phenotype of female CD from pre- to postpuberty and related neuroendocrine and ANS function as well as moderating, mediating and direct risk factors to identify distinct homogeneous subtypes to guide targeted future treatment approaches. We translate knowledge of neuropsychological and neurobiological characteristics into targeted intervention by performing a randomised controlled trial of an innovative 16-week DBT-CD-A psychological treatment program focussing on emotion processing. The effect oxytocin and serotonin on neural function underlying emotion processing and aggression will be studied in a female animal model and two proof of concept pharmaco-challenge studies. We also target several societal and education objectives. Our consortium brings together strong clinical and basic science expertise on paediatric CD, including a number of SMEs and a professional management company.

Field of science

  • /social sciences/psychology/psychotherapy
  • /natural sciences/biological sciences/neurobiology

Call for proposal

FP7-HEALTH-2013-INNOVATION-1
See other projects for this call

Funding Scheme

CP-FP - Small or medium-scale focused research project

Coordinator

JOHANN WOLFGANG GOETHE-UNIVERSITATFRANKFURT AM MAIN
Address
Theodor W Adorno Platz 1
60323 Frankfurt Am Main
Germany
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 1 383 778,89
Administrative Contact
Christine Freitag (Prof.)

Participants (20)

UNIVERSITAETSKLINIKUM AACHEN
Germany
EU contribution
€ 731 806,32
Address
Pauwelsstrasse 30
52074 Aachen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Volker Legewie (Mr.)
STICHTING VU
Netherlands
EU contribution
€ 309 373,02
Address
De Boelelaan 1105
1081 HV Amsterdam
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Michel Telkamp
UNIVERSITY OF SOUTHAMPTON
United Kingdom
EU contribution
€ 495 413,70
Address
Highfield
SO17 1BJ Southampton
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Dewi Tan (Ms.)
UNIVERSITAT BASEL
Switzerland
EU contribution
€ 569 136,25
Address
Petersplatz 1
4051 Basel
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Christina Stadler (Prof.)
UNIVERSITATSKLINIKUM HEIDELBERG
Germany
EU contribution
€ 587 310
Address
Im Neuenheimer Feld 672
69120 Heidelberg
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Thorsten Brietz (Mr.)
THE UNIVERSITY OF BIRMINGHAM
United Kingdom
EU contribution
€ 509 686,20
Address
Edgbaston
B15 2TT Birmingham
Activity type
Higher or Secondary Education Establishments
Administrative Contact
May Chung (Ms.)
THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN

Participation ended

Ireland
EU contribution
€ 22 130,90
Address
College Green
2 Dublin
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Deirdre Savage (Ms.)
UNIVERSITAET REGENSBURG
Germany
EU contribution
€ 254 529
Address
Universitatsstrasse 31
93053 Regensburg
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Johanna Kronberger
FUNDACIO MUTUA DE TERRASSA PER A LA DOCENCIA I RECERCA BIOMEDICA I SOCIAL FUNDACIO PRIVADA CATALANA

Participation ended

Spain
EU contribution
€ 42 290,64
Address
Plaza Dr Robert 5
08221 Terrassa
Activity type
Research Organisations
Administrative Contact
Amaia Hervas (Dr.)
FUNDACION VASCA DE INNOVACION E INVESTIGACION SANITARIAS
Spain
EU contribution
€ 62 081
Address
Ronda De Azkue,1
48902 Barakaldo
Activity type
Research Organisations
Administrative Contact
Javier Segura (Mr.)
SZEGEDI TUDOMANYEGYETEM
Hungary
EU contribution
€ 32 096
Address
Dugonics Ter 13
6720 Szeged
Activity type
Higher or Secondary Education Establishments
Administrative Contact
ágnes Vetró (Prof.)
ETHNIKO KAI KAPODISTRIAKO PANEPISTIMIO ATHINON
Greece
EU contribution
€ 49 515,01
Address
6 Christou Lada Str
10561 Athina
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Efstathia Kafentzi (Mrs.)
GENEWAKE GMBH

Participation ended

Germany
EU contribution
€ 11 050,70
Address
Floriansbogen 2-4
82061 Neuried
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Robert Loewe (Dr.)
VARIONOSTIC GMBH
Germany
EU contribution
€ 404 087
Address
Soflinger Strasse 100
89077 Ulm
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Uwe Gerstenmaier (Mr.)
DAACRO GMBH & CO KG
Germany
EU contribution
€ 114 472
Address
Novalisstrasse 12A
54295 Trier
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Juliane Hellhammer (Dr.)
GABO:MI GESELLSCHAFT FUR ABLAUFORGANISATION:MILLIARIUM MBH & CO KG

Participation ended

Germany
EU contribution
€ 170 266
Address
Oskar Von Miller Ring 29
80333 Muenchen
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Birgit Fuchs (Mrs.)
CARDIFF UNIVERSITY
United Kingdom
EU contribution
€ 31 370
Address
Newport Road 30-36
CF24 ODE Cardiff
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Keith Sexton (Dr.)
ARTTIC
France
EU contribution
€ 120 963
Address
Rue Du Dessous Des Berges 58A
75013 Paris
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Martin Dietz (Dr.)
GENXPRO GMBH
Germany
EU contribution
€ 97 885,37
Address
Altenhofter Allee 3
60438 Frankfurt
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Cornelia Lenhart (Ms.)
STICHTING VUMC
Netherlands
Address
De Boelelaan 1117
1081 HV Amsterdam
Activity type
Research Organisations
Administrative Contact
Cedric Van Der Meulen (Dr.)