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Multidisciplinary Approaches to Translational Research In Conduct Syndromes

Objective

Conduct Disorder (CD) is the key paediatric disorder characterized by severe aggression. It is heterogeneous, and our understanding of the neurobiology to subtype aggression is limited. MATRICS is a multidisciplinary consortium of academic partners and SMEs that focuses on the subtyping of aggression both within CD and of the broader cross-disorder trait of aggression. MATRICS will test the hypothesis that reactive and instrumental aggression result from aberrant autonomic reactivity coupled to the differential impairment of three basic neural functions: 1) regulation of control mechanisms of aggression, 2) emotional value rating of others, and 3) empathy and moral decision making. MATRICS will employ the same psychological tasks assessing 1), 2) and 3) in animal aggression models and human CD samples concurrent with the assessment of neural, neurochemical, (epi)-genetic and autonomic nervous system markers. These data will be integrated with matching expression profiling from neurons derived from CD IPSCs. MATRICS also examines how environmental risks, whether or not they interact with genetic factors, are translated in epigenetic and neural changes. MATRICS will data-mine existing large integrated imaging-genetics cohorts (NeuroIMAGE; IMAGEN) and prospective cohorts (TRAILS; ALSPAC) with follow-up into adulthood and the (epi)genetic profiling of the PERS CD cohort, and collect a large new CD cohort and controls for collection of MRI, (epi)-genetic, biochemical and environmental measures. Bayesian machine learning tools will integrate multi-source and multi-level data, and generate predictive algorithms of persistent aggression into adulthood. MATRICS will identify new potentially ‘druggable’ targets, develop novel animal models and conduct pilot medication and neuro/biofeedback studies in high-risk and CD patients. MATRICS builds on existing fruitful EU collaborations which maximises feasibility and successful output.

Field of science

  • /natural sciences/computer and information sciences/artificial intelligence/machine learning

Call for proposal

FP7-HEALTH-2013-INNOVATION-1
See other projects for this call

Funding Scheme

CP-FP - Small or medium-scale focused research project

Coordinator

STICHTING KATHOLIEKE UNIVERSITEIT
Address
Geert Grooteplein Noord 9
6525 EZ Nijmegen
Netherlands
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 1 206 757,61
Administrative Contact
Maarten Van Langen (Mr.)

Participants (19)

ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE
Switzerland
EU contribution
€ 270 740
Address
Batiment Ce 3316 Station 1
1015 Lausanne
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Carmen Sandi (Prof.)
ISTITUTO SUPERIORE DI SANITA
Italy
EU contribution
€ 267 900
Address
Viale Regina Elena 299
00161 Roma
Activity type
Research Organisations
Administrative Contact
Rosa Maria Martoccia (Dr.)
GENOWAY
France
EU contribution
€ 65 630
Address
31 Rue Saint Jean De Dieu Technopark 2
69007 Lyon
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Gaelle Lebel (Ms.)
KING'S COLLEGE LONDON
United Kingdom
EU contribution
€ 886 928
Address
Strand
WC2R 2LS London
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Paul Labbett (Mr.)
ZENTRALINSTITUT FUER SEELISCHE GESUNDHEIT
Germany
EU contribution
€ 238 675
Address
Square J 5
68159 Mannheim
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Tobias Banaschewski (Prof.)
UNIVERSITY OF DUNDEE

Participation ended

United Kingdom
EU contribution
€ 15 445,76
Address
Nethergate
DD1 4HN Dundee
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Zoe Kidd (Mrs.)
ACADEMISCH ZIEKENHUIS GRONINGEN
Netherlands
EU contribution
€ 184 288
Address
Hanzeplein 1
9713 GZ Groningen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Johanna M. Van Apeldoorn (Ms.)
THE UNIVERSITY OF EXETER
United Kingdom
EU contribution
€ 300 000
Address
The Queen's Drive Northcote House
EX4 4QJ Exeter
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Gaynor Hughes (Ms.)
UNIVERSITA DEGLI STUDI DI CAGLIARI
Italy
EU contribution
€ 158 240,24
Address
Via Universita 40
09124 Cagliari
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Alessandro Zuddas (Prof.)
neuroConn GmbH
Germany
EU contribution
€ 98 700
Address
Albert-einstein-strasse 3
98693 Ilmenau
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Ralf Kersten (Prof.)
UNIVERSITAET ULM
Germany
EU contribution
€ 54 508
Address
Helmholtzstrasse 16
89081 Ulm
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Frank Gleixner (Mr.)
CENTRE HOSPITALIER UNIVERSITAIRE MONTPELLIER
France
EU contribution
€ 49 200
Address
Avenue Du Doyen Gaston Giraud 191
34000 Montpellier
Activity type
Other
Administrative Contact
Valérie Handweiler (Mrs.)
PHENOSYS GMBH
Germany
EU contribution
€ 60 000
Address
Schumannstrasse 18
10117 Berlin
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
York Winter (Prof.)
Concentris Research Management GmbH
Germany
EU contribution
€ 313 700
Address
Ludwigstr. 4
D-82256 Fürstenfeldbruck
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Ameli Schwalber (Dr.)
CONSORCI INSTITUT D'INVESTIGACIONS BIOMEDIQUES AUGUST PI I SUNYER
Spain
EU contribution
€ 18 838,09
Address
Calle Rossello 149 Puerta Bjs
08036 Barcelona
Activity type
Other
Administrative Contact
Pastora Martinez Samper (Dr.)
SERVICIO MADRILENO DE SALUD
Spain
EU contribution
€ 17 869,30
Address
Plaza Carlos Trias Bertran 7
28020 Madrid
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Administrative Contact
Bardinet Thierry (Mr.)
CERTAIN INDEXES LIMITED
United Kingdom
EU contribution
€ 167 580
Address
Park Road 4 Sileby
LE12 7TJ Loughborough
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Greg Prescott (Mr.)
DRUG TARGET ID BV
Netherlands
EU contribution
€ 50 000
Address
Toernooiveld 200
6525 EC Nijmegen
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Geert Poelmans (Dr.)
Fondazione Stella Maris
Italy
EU contribution
€ 75 000
Address
Viale Del Tirreno 331
56118 Pisa
Activity type
Research Organisations
Administrative Contact
Barbara Collina Grenci (Dr.)