Objective Conduct Disorder (CD) is the key paediatric disorder characterized by severe aggression. It is heterogeneous, and our understanding of the neurobiology to subtype aggression is limited. MATRICS is a multidisciplinary consortium of academic partners and SMEs that focuses on the subtyping of aggression both within CD and of the broader cross-disorder trait of aggression. MATRICS will test the hypothesis that reactive and instrumental aggression result from aberrant autonomic reactivity coupled to the differential impairment of three basic neural functions: 1) regulation of control mechanisms of aggression, 2) emotional value rating of others, and 3) empathy and moral decision making. MATRICS will employ the same psychological tasks assessing 1), 2) and 3) in animal aggression models and human CD samples concurrent with the assessment of neural, neurochemical, (epi)-genetic and autonomic nervous system markers. These data will be integrated with matching expression profiling from neurons derived from CD IPSCs. MATRICS also examines how environmental risks, whether or not they interact with genetic factors, are translated in epigenetic and neural changes. MATRICS will data-mine existing large integrated imaging-genetics cohorts (NeuroIMAGE; IMAGEN) and prospective cohorts (TRAILS; ALSPAC) with follow-up into adulthood and the (epi)genetic profiling of the PERS CD cohort, and collect a large new CD cohort and controls for collection of MRI, (epi)-genetic, biochemical and environmental measures. Bayesian machine learning tools will integrate multi-source and multi-level data, and generate predictive algorithms of persistent aggression into adulthood. MATRICS will identify new potentially ‘druggable’ targets, develop novel animal models and conduct pilot medication and neuro/biofeedback studies in high-risk and CD patients. MATRICS builds on existing fruitful EU collaborations which maximises feasibility and successful output. Fields of science natural sciencesbiological sciencesneurobiologymedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsnatural sciencescomputer and information sciencesartificial intelligencemachine learning Programme(s) FP7-HEALTH - Specific Programme "Cooperation": Health Topic(s) HEALTH.2013.2.2.1-3 - Paediatric conduct disorders characterised by aggressive traits and/or social impairment: from preclinical research to treatment Call for proposal FP7-HEALTH-2013-INNOVATION-1 See other projects for this call Funding Scheme CP-FP - Small or medium-scale focused research project Coordinator STICHTING RADBOUD UNIVERSITEIT Address Houtlaan 4 6525 XZ Nijmegen Netherlands See on map Region Oost-Nederland Gelderland Arnhem/Nijmegen Activity type Higher or Secondary Education Establishments Administrative Contact Maarten Van Langen (Mr.) Links Contact the organisation Opens in new window Website Opens in new window EU contribution € 1 256 728,85 Participants (19) Sort alphabetically Sort by EU Contribution Expand all Collapse all ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE Switzerland EU contribution € 270 740,00 Address Batiment ce 3316 station 1 1015 Lausanne See on map Region Schweiz/Suisse/Svizzera Région lémanique Vaud Activity type Higher or Secondary Education Establishments Administrative Contact Carmen Sandi (Prof.) Links Contact the organisation Opens in new window Website Opens in new window ISTITUTO SUPERIORE DI SANITA Italy EU contribution € 267 900,00 Address Viale regina elena 299 00161 Roma See on map Region Centro (IT) Lazio Roma Administrative Contact Rosa Maria Martoccia (Dr.) Links Contact the organisation Opens in new window Website Opens in new window GENOWAY France EU contribution € 65 630,00 Address 31 rue saint jean de dieu technopark 2 69007 Lyon See on map Region Auvergne-Rhône-Alpes Rhône-Alpes Rhône Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Gaelle Lebel (Ms.) Links Contact the organisation Opens in new window Website Opens in new window KING'S COLLEGE LONDON United Kingdom EU contribution € 886 928,00 Address Strand WC2R 2LS London See on map Region London Inner London — West Westminster Activity type Higher or Secondary Education Establishments Administrative Contact Paul Labbett (Mr.) Links Contact the organisation Opens in new window Website Opens in new window ZENTRALINSTITUT FUER SEELISCHE GESUNDHEIT Germany EU contribution € 238 675,00 Address Square j 5 68159 Mannheim See on map Region Baden-Württemberg Karlsruhe Mannheim, Stadtkreis Activity type Higher or Secondary Education Establishments Administrative Contact Tobias Banaschewski (Prof.) Links Contact the organisation Opens in new window Website Opens in new window UNIVERSITY OF DUNDEE Participation ended United Kingdom EU contribution € 15 445,76 Address Nethergate DD1 4HN Dundee See on map Region Scotland Eastern Scotland Angus and Dundee City Activity type Higher or Secondary Education Establishments Administrative Contact Zoe Kidd (Mrs.) Links Contact the organisation Opens in new window Website Opens in new window ACADEMISCH ZIEKENHUIS GRONINGEN Netherlands EU contribution € 184 288,00 Address Hanzeplein 1 9713 GZ Groningen See on map Region Noord-Nederland Groningen Overig Groningen Activity type Higher or Secondary Education Establishments Administrative Contact Johanna M. Van Apeldoorn (Ms.) Links Contact the organisation Opens in new window Website Opens in new window THE UNIVERSITY OF EXETER United Kingdom EU contribution € 300 000,00 Address The queen's drive northcote house EX4 4QJ Exeter See on map Region South West (England) Devon Devon CC Activity type Higher or Secondary Education Establishments Administrative Contact Gaynor Hughes (Ms.) Links Contact the organisation Opens in new window Website Opens in new window UNIVERSITA DEGLI STUDI DI CAGLIARI Italy EU contribution € 127 240,00 Address Via universita 40 09124 Cagliari See on map Region Isole Sardegna Cagliari Activity type Higher or Secondary Education Establishments Administrative Contact Alessandro Zuddas (Prof.) Links Contact the organisation Opens in new window NEUROCONN GMBH Germany EU contribution € 98 700,00 Address Albert-einstein-strasse 3 98693 Ilmenau See on map Region Thüringen Thüringen Ilm-Kreis Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Ralf Kersten (Prof.) Links Contact the organisation Opens in new window Website Opens in new window UNIVERSITAET ULM Germany EU contribution € 54 508,00 Address Helmholtzstrasse 16 89081 Ulm See on map Region Baden-Württemberg Tübingen Ulm, Stadtkreis Activity type Higher or Secondary Education Establishments Administrative Contact Frank Gleixner (Mr.) Links Contact the organisation Opens in new window Website Opens in new window CENTRE HOSPITALIER UNIVERSITAIRE MONTPELLIER France EU contribution € 49 200,00 Address Avenue du doyen gaston giraud 191 34000 Montpellier See on map Region Occitanie Languedoc-Roussillon Hérault Activity type Research Organisations Administrative Contact Valérie Handweiler (Mrs.) Links Contact the organisation Opens in new window Website Opens in new window PHENOSYS GMBH Germany EU contribution € 60 000,00 Address Schumannstrasse 18 10117 Berlin See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact York Winter (Prof.) Links Contact the organisation Opens in new window Website Opens in new window CONCENTRIS RESEARCH MANAGEMENT GMBH Germany EU contribution € 313 700,00 Address Ludwigstr. 4 82256 Furstenfeldbruck See on map Region Bayern Oberbayern Fürstenfeldbruck Administrative Contact Ameli Schwalber (Dr.) Links Contact the organisation Opens in new window Website Opens in new window CONSORCI INSTITUT D'INVESTIGACIONS BIOMEDIQUES AUGUST PI I SUNYER Spain EU contribution € 18 838,09 Address Calle rossello 149 puerta bjs 08036 Barcelona See on map Region Este Cataluña Barcelona Activity type Other Administrative Contact Pastora Martinez Samper (Dr.) Links Contact the organisation Opens in new window Website Opens in new window SERVICIO MADRILENO DE SALUD Spain EU contribution € 17 869,30 Address Plaza carlos trias bertran 7 28020 Madrid See on map Region Comunidad de Madrid Comunidad de Madrid Madrid Administrative Contact Bardinet Thierry (Mr.) Links Contact the organisation Opens in new window Website Opens in new window CERTAIN INDEXES LIMITED United Kingdom EU contribution € 167 580,00 Address Park road 4 sileby LE12 7TJ Loughborough See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Greg Prescott (Mr.) Links Contact the organisation Opens in new window Website Opens in new window DRUG TARGET ID BV Netherlands EU contribution € 50 000,00 Address Toernooiveld 200 6525 EC Nijmegen See on map Region Oost-Nederland Gelderland Arnhem/Nijmegen Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Geert Poelmans (Dr.) Links Contact the organisation Opens in new window Fondazione Stella Maris Italy EU contribution € 56 029,00 Address Viale del tirreno 331 56118 Pisa See on map Region Centro (IT) Toscana Pisa Administrative Contact Barbara Collina Grenci (Dr.) Links Contact the organisation Opens in new window Website Opens in new window
