Objective Resistance to traditional antibiotics is a rapidly increasing problem that in a few years could make infections impossible to treat and bring the state of medical care back to the pre-antibiotic era from the beginning of the last century. Antimicrobial peptides (AMPs) have a huge potential as new therapeutics against infectious diseases as they are less prone to induce resistance due to their fast and non-specific mechanism of action. The aim of FORMAMP is to explore a number of innovative formulation and delivery strategies based on nanotechnology in order to improve the efficiency and stability of AMPs in clinical development. Functional delivery systems that can be applied directly on the infected site will be developed for treatment of infections in skin and burn wounds, as well as lung infections caused by Methicillin-resistant Staphylococcus aureus (MRSA), Pseudomonas aeruginosa and Mycobacterium tuberculosis (MTB). Formulation and delivery strategies to prevent and treat biofilm formation related to these conditions will be developed. Different nanoformulation platforms, particularly promising for peptide delivery, controlled release strategies and technologies against proteolytic degradation of peptides will be evaluated in the project. These include lipid-based systems such as lipidic nanocapsules, polymer-based structures such as dendrimers and microgels as well as nanostructured mesoporous silica. The possibility to formulate the nanostructured materials into efficient drug delivery systems such as a topical spray or gel and pulmonary aerosol will be evaluated. The effect of nanoformulated AMPs will be evaluated with state-of-the art in vitro models and in vivo models. The results of this interdisciplinary project will generate efficient treatment strategies combatting one of the largest threats to our health care system today, reducing healthcare costs and expand the growth of European enterprises within the field of pharmaceutics and nanomaterials. Fields of science natural sciencesbiological sciencesbiochemistrybiomoleculesmedical and health scienceshealth sciencesinfectious diseasesmedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsantibioticsengineering and technologynanotechnologynano-materials Programme(s) FP7-NMP - Specific Programme "Cooperation": Nanosciences, Nanotechnologies, Materials and new Production Technologies Topic(s) NMP.2013.1.2-2 - Nanotherapeutics to treat bacterial infectious diseases Call for proposal FP7-NMP-2013-LARGE-7 See other projects for this call Funding Scheme CP-IP - Large-scale integrating project Coordinator RISE RESEARCH INSTITUTES OF SWEDEN AB Address Brinellgatan 4 501 15 Boras Sweden See on map Region Södra Sverige Västsverige Västra Götalands län Activity type Research Organisations Administrative Contact Lovisa Ringstad (Dr.) Links Contact the organisation Opens in new window Website Opens in new window EU contribution € 1 523 012,20 Participants (15) Sort alphabetically Sort by EU Contribution Expand all Collapse all LUNDS UNIVERSITET Sweden EU contribution € 675 040,00 Address Paradisgatan 5c 22100 Lund See on map Region Södra Sverige Sydsverige Skåne län Activity type Higher or Secondary Education Establishments Administrative Contact Artur Schmidtchen (Prof.) Links Contact the organisation Opens in new window Website Opens in new window UPPSALA UNIVERSITET Sweden EU contribution € 583 440,00 Address Von kraemers alle 4 751 05 Uppsala See on map Region Östra Sverige Östra Mellansverige Uppsala län Activity type Higher or Secondary Education Establishments Administrative Contact Eva Nises Ahlgren (Mrs.) Links Contact the organisation Opens in new window Website Opens in new window UNIVERSITAET ULM Germany EU contribution € 515 600,00 Address Helmholtzstrasse 16 89081 Ulm See on map Region Baden-Württemberg Tübingen Ulm, Stadtkreis Activity type Higher or Secondary Education Establishments Administrative Contact Michaela Schuhmacher (Mrs.) Links Contact the organisation Opens in new window Website Opens in new window ACADEMISCH ZIEKENHUIS GRONINGEN Netherlands EU contribution € 530 868,00 Address Hanzeplein 1 9713 GZ Groningen See on map Region Noord-Nederland Groningen Overig Groningen Activity type Higher or Secondary Education Establishments Administrative Contact Peter Braun (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Pergamum AB Sweden EU contribution € 250 800,00 Address Kisp fogdevreten 2 171 65 Solna See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Ulrika Wennberg (Ms.) Links Contact the organisation Opens in new window Website Opens in new window LAKEMEDELSVERKET Sweden EU contribution € 180 373,00 Address Dag hammarskjolds vag 42 75103 Uppsala See on map Region Östra Sverige Östra Mellansverige Uppsala län Activity type Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments) Administrative Contact Ambjörn Lindqvist (Mr.) Links Contact the organisation Opens in new window Website Opens in new window SP PROCESS DEVELOPMENT AB Sweden EU contribution € 703 492,00 Address Po box 857 501 15 Boras See on map Region Södra Sverige Västsverige Västra Götalands län Activity type Research Organisations Administrative Contact Bo Lassen (Dr.) Links Contact the organisation Opens in new window Website Opens in new window POLYMER FACTORY SWEDEN AB Sweden EU contribution € 353 552,00 Address Teknikringen 48 1 tr 114 28 Stockholm See on map Region Östra Sverige Stockholm Stockholms län Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Andreas Nyström (Dr.) Links Contact the organisation Opens in new window Website Opens in new window UNIVERSITE D'ANGERS France EU contribution € 528 480,00 Address Rue de rennes 40 49035 Angers cedex 01 See on map Region Pays de la Loire Pays de la Loire Maine-et-Loire Activity type Higher or Secondary Education Establishments Administrative Contact Patrick Saulnier (Prof.) Links Contact the organisation Opens in new window Website Opens in new window CENTRE HOSPITALIER UNIVERSITAIRE D'ANGERS France EU contribution € 199 680,00 Address Rue larrey 4 49100 Angers See on map Region Pays de la Loire Pays de la Loire Maine-et-Loire Activity type Other Administrative Contact Amina Moussa (Mrs.) Links Contact the organisation Opens in new window Website Opens in new window KUNGLIGA TEKNISKA HOEGSKOLAN Sweden EU contribution € 662 040,00 Address Brinellvagen 8 100 44 Stockholm See on map Region Östra Sverige Stockholm Stockholms län Activity type Higher or Secondary Education Establishments Administrative Contact Barbara Karan (Ms.) Links Contact the organisation Opens in new window Website Opens in new window INHALATION SCIENCES SWEDEN AB Sweden EU contribution € 510 637,80 Address Halsovagen 7 141 57 Huddinge See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Fredrik Sjövall (Mr.) Links Contact the organisation Opens in new window Website Opens in new window XSPRAY PHARMA AB (PUBL) Sweden EU contribution € 367 240,00 Address Gunnar asplunds alle 32 171 63 Solna See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Magnus Andersson (Dr.) Links Contact the organisation Opens in new window Website Opens in new window ADENIUM BIOTECH APS Denmark EU contribution € 232 810,00 Address Ole maaloesvej 3 2200 Kobenhavn See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Peter Nordkild (Dr.) Links Contact the organisation Opens in new window Website Opens in new window POLYPEPTIDE LABORATORIES (SWEDEN) AB Sweden EU contribution € 128 429,00 Address Box 30089 200 61 Limhamn See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Lars Andersson (Dr.) Links Contact the organisation Opens in new window Website Opens in new window
