Skip to main content

Enhanced Process Monitoring and Control Technology to Accelerate Development of Bioresorbable Polymeric Medical Devices

Objective

The manufacture of bioresorbable medical devices for temporary implantation inside the human body is growing into a high-value industry with many benefits over traditional devices. Bioresorbable devices do not need a removal operation, reducing patient trauma and significant healthcare costs. Due to the ability to add antibacterial or antibiotic drugs and to control the release rate at the implant site, such devices can reduce the number of post-operative complications and open up possibilities for new therapies.
However, development times for new devices can be lengthy and extremely expensive. Bioresorbable materials have a high cost and are difficult to process, resulting in high scrap rates. The addition of fillers such as bioactive particles further complicate the manufacture. In Bio-PolyTec, sensor technology - centering on optical spectroscopic techniques - will be developed for in-process monitoring of the key quality measures of polymer degradation and additive dispersion. The availability of this information in real-time rather than after time-consuming and expensive laboratory testing represents a significant improvement in Quality Control for bioresorbable devices as well as enabling better process control. The influence of typical processing procedures on the degradation and mixing and hence subsequent bioresorption/release behaviour and mechanical properties will be fully investigated for the commercial products of the consortium SMEs to optimise their processes to achieve specific and consistent product requirements. In particular the processing of Polylactic Acid (PLA) and dispersion of bioactive Calcium Phosphate particles for orthopaedic implants will be investigated among other polymer/filler systems.
The innovations in sensor technology will extend outside the consortium to enable other device manufacturers to reduce scrap rates and hence production costs for bioresorbable devices. The 'trial-and-error' guesswork is taken out of the process development stage for new products, significantly reducing the time and cost and stimulating activity in the market. Possible batch-to-batch variation will be eliminated, avoiding adverse behaviour of the products after implantation in a patient.

Field of science

  • /social sciences/economics and business/business and management/commerce
  • /natural sciences/chemical sciences/inorganic chemistry/inorganic compounds
  • /natural sciences/physical sciences/theoretical physics/particles
  • /engineering and technology/industrial biotechnology/biomaterials/bioplastics/polylactic acid
  • /medical and health sciences/medical biotechnology/medical bioproducts/implants

Call for proposal

FP7-SME-2013
See other projects for this call

Funding Scheme

BSG-SME - Research for SMEs

Coordinator

INSTITUTE OF TECHNOLOGY SLIGO - ITS
Address
Ballinode - Ash Lane
F56 Sligo
Ireland
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 44 608,80
Administrative Contact
Marion Mcafee (Dr.)

Participants (7)

SCAFFDEX OY
Finland
EU contribution
€ 171 349,50
Address
Kalkunkatu 21 B
33330 Tampere
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Tuija Annala (Ms)
INNOVATIVE POLYMER COMPOUNDS LIMITED
Ireland
EU contribution
€ 156 199,75
Address
Lower Leeson Street 42 Ncc House
2 Dublin
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Joe Molloy (Mr.)
FOS FASEROPTISCHE SYSTEME MESSTECHNIK GMBH
Germany
EU contribution
€ 349 001,25
Address
Rutgersstrasse 40
24790 Schacht Audorf
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Erhard Giese (Dr.)
THE QUEEN'S UNIVERSITY OF BELFAST
United Kingdom
EU contribution
€ 7 499,20
Address
University Road Lanyon Building
BT7 1NN Belfast
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Fraser Buchanan (Prof.)
TTY-SAATIO
Finland
EU contribution
€ 7 504
Address
Korkeakoulunkatu 10
33720 Tampere
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Minna Kellomäki (Prof.)
PURAC BIOCHEM BV
Netherlands
EU contribution
€ 6 690
Address
Arkelsedijk 46
4206AC Gorinchem
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Marc-Anton Kruft (Dr.)
PLASMA BIOTAL LIMITED
United Kingdom
EU contribution
€ 44 743,45
Address
Meverill Road - Industrial Estate Unit 5 Unit 5
SK17 8PY Tideswell
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Paul Steverson (Mr.)