Objective Antimicrobial agents, such as antibiotics, have dramatically reduced the number of deaths from infectious diseases over the last 70 years. However, through overuse and misuse of these agents, many micro-organisms have developed antimicrobial resistance. Oligonucleotide therapeutics have the potential to become the new class of antibacterials capable of treating a broad range of infections. By acting on novel targets, they circumvent current resistance mechanisms and with judicious use, can suppress the rise of future resistance.DNA-TRAP will build on a platform technology that uses proprietary nucleic acid-based Transcription Factor Decoys (TFDs) that act on novel genomic targets by capturing key regulatory proteins to block essential bacterial genes and defeat infection. Taking forward newly emerging insights and expertise that exists within each of the partners and through the mutual secondment of researchers, the project aims to develop a new class of nanoparticulate antibacterials capable of meeting the clinical challenge of drug-resistant infections such as Clostridium difficile and Pseudomonas aeruginosa.DNA-TRAP will establish a lasting, international partnership for transfer of knowledge between Industry and Academia in the field of nanomedicine. Exchange of knowledge and expertise between the partners is key to establishing the fundamental properties of nanostructured drug delivery systems to treat bacterial infections and through this, provide the basis for building a manufacturing platform to advance the experimental therapeutic into clinical trials.17 researchers in the field of drug development and delivery from 2 commercial (SME) and 2 non-commercial partners across 2 member states, will have the opportunity to share and acquire new complementary and multidisciplinary knowledge, through inter-sectoral and interdisciplinary exchange, allowing for the development of new solutions and the establishment of further joint research projects. Fields of science medical and health sciencesbasic medicinepharmacology and pharmacydrug discoverynatural sciencesbiological sciencesmicrobiologybacteriologymedical and health scienceshealth sciencesinfectious diseasesmedical and health sciencesmedical biotechnologynanomedicinemedical and health sciencesbasic medicinepharmacology and pharmacydrug resistanceantibiotic resistance Programme(s) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Topic(s) FP7-PEOPLE-2013-IAPP - Marie Curie Action: "Industry-Academia Partnerships and Pathways" Call for proposal FP7-PEOPLE-2013-IAPP See other projects for this call Funding Scheme MC-IAPP - Industry-Academia Partnerships and Pathways (IAPP) Coordinator UNIVERSITY OF EAST ANGLIA EU contribution € 801 239,73 Address EARLHAM ROAD NR4 7TJ Norwich United Kingdom See on map Region East of England East Anglia Norwich and East Norfolk Activity type Higher or Secondary Education Establishments Administrative Contact Christopher Morris (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Participants (5) Sort alphabetically Sort by EU Contribution Expand all Collapse all CONSORZIO INTERUNIVERSITARIO PERLO SVILUPPO DEI SISTEMI A GRANDE INTERFASE Italy EU contribution € 560 610,14 Address VIA DELLA LASTRUCCIA 3 50019 Firenze See on map Region Centro (IT) Toscana Firenze Activity type Research Organisations Administrative Contact Debora Berti (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data PROCARTA BIOSYSTEMS LIMITED Participation ended United Kingdom EU contribution € 388 220,14 Address BANKSIDE 300 PEACHMAN WAY NR7 0LB NORWICH See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Kostas Hatzixanthis (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data NANOVECTOR SRL Italy EU contribution € 551 331,87 Address VIA LIVORNO 60 10144 Torino See on map Region Nord-Ovest Piemonte Torino Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Paolo Gasco (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data TECREA LIMITED United Kingdom EU contribution € 25 520,00 Address ROYAL COLLEGE STREET 2 NW1 0NH LONDON See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Liam Good (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data KUECEPT LIMITED United Kingdom EU contribution € 44 109,12 Address STATION CLOSE 16-17 EN6 1TL POTTERS BAR HERTS See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Cristina Freire (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data
