Objectif Plant senescence is a genetically controlled process modulated by environmental factors. A number of genes that influence ageing have been identified over the recent years; while mutations in most of them accelerate senescence, some delay senescence and thus extend lifespan. Experimental evidence strongly indicates that many more genes than functionally characterized so far contribute to the control of plant ageing. Moreover, very little is currently known about how these genes interact and to what extent developmental signals, environmental factors, phytohormones, and in particular the circadian clock modulate their activity and interactions. Recent research shows that reactive oxygen species (ROS) play a critical role in the control of senescence. The aim of this project therefore is to uncover new elements of the ROS regulatory pathway that modulate senescence in Arabidopsis thaliana and to unravel the mechanisms by which these genes interact with each other and with the internal clock. Mutants with accelerated and delayed senescence, previously isolated by our teams, will be subjected to genetic, genomic, and biochemical analyses. Identification of the mutated genes causing the altered senescence, molecular analysis by RNAseq and qRT-PCR, proteome and metabolome profiling will help to understand how these genes regulate lifespan. Staff exchange is of crucial importance to the success of the project. The Bulgarian partner is an expert in ROS signaling, the German collaborator has expertise in transcriptional regulation of ROS-related genes, and the New Zealand partner brings in knowledge about the genetics and physiology of ageing and ROS - circadian clock interactions. Thus, the European and New Zealand partners mutually complement each other in their expertise and capabilities. Unraveling the genetic mechanisms of plant ageing and lifespan regulation is of both, fundamental and practical importance for generating crops with improved yield and shelf life. Champ scientifique sciences naturellessciences biologiquesbiochimiebiomoléculeprotéinesprotéomiquesciences naturellessciences biologiquesgénétiquemutationsciences médicales et de la santémédecine fondamentalephysiologiesciences agricolesagriculture, sylviculture et pêcheagriculture Programme(s) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Thème(s) FP7-PEOPLE-2013-IRSES - Marie Curie Action "International Research Staff Exchange Scheme" Appel à propositions FP7-PEOPLE-2013-IRSES Voir d’autres projets de cet appel Régime de financement MC-IRSES - International research staff exchange scheme (IRSES) Coordinateur INSTITUTE OF MOLECULAR BIOLOGY AND BIOTECHNOLOGY Adresse Ruski bulevard 105 4000 Plovdiv Bulgarie Voir sur la carte Région Югозападна и Южна централна България Южен централен Пловдив Type d’activité Research Organisations Contact administratif Tsanko Gechev (Dr.) Liens Contacter l’organisation Opens in new window Contribution de l’UE Aucune donnée Participants (1) Trier par ordre alphabétique Trier par contribution de l’UE Tout développer Tout réduire UNIVERSITAET POTSDAM Allemagne Contribution de l’UE € 23 100,00 Adresse Am neuen palais 10 14469 Potsdam Voir sur la carte Région Brandenburg Brandenburg Potsdam Type d’activité Higher or Secondary Education Establishments Contact administratif Regina Gerber (Dr.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Autres sources de financement Aucune donnée
