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Synthetic Biology for the production of functional peptides

Objective

"Peptides are among the most versatile natural products that nature provides to cater for a broad set of biotechnological applications ranging from antibiotics to personal hygiene. Their diversity comes from a broad variety of posttranslational modifications that is used to provide additional functionality beyond to what is possible with the classic proteinogenic set of 20 amino acids. In SYNPEPTIDE, we want to recruit such additional functionality for rational molecular design purposes in order to facilitate the design and the production of synthetic peptides.
To this end, we intend to standardize the integration of chemical diversity in peptide design and production by the following activities: [i] translational integration of chemically suitable non-canonical amino acids for posttranslational in vivo and in vitro modification; [ii] systematic recruitment of selected highly relevant posttranslational modifications from natural peptide synthesis routes into the design process. These activities will ultimately allow to drastically expand our arsenal of functionalities in the design of novel molecules and our capacity to reliably produce them."

Field of science

  • /natural sciences/biological sciences/synthetic biology
  • /natural sciences/chemical sciences/organic chemistry/amines

Call for proposal

FP7-KBBE-2013-7-single-stage
See other projects for this call

Funding Scheme

CP-TP - Collaborative Project targeted to a special group (such as SMEs)

Coordinator

EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH
Address
Raemistrasse 101
8092 Zuerich
Switzerland
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 1 892 804,80
Administrative Contact
Sven Panke (Prof.)

Participants (6)

RIJKSUNIVERSITEIT GRONINGEN
Netherlands
EU contribution
€ 939 363,20
Address
Broerstraat 5
9712CP Groningen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Dick Veldhuis (Dr.)
TECHNISCHE UNIVERSITAT BERLIN
Germany
EU contribution
€ 845 680
Address
Strasse Des 17 Juni 135
10623 Berlin
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Silke Hönert (Mrs.)
FGEN GMBH
Switzerland
EU contribution
€ 719 163
Address
Hochbergerstrasse 60C
4057 Basel
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Martin Held (Dr.)
UNIVERSITAET REGENSBURG
Germany
EU contribution
€ 518 360
Address
Universitatsstrasse 31
93053 Regensburg
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Johanna Kronberger (Ms.)
LANTHIOPEP BV
Netherlands
EU contribution
€ 269 052
Address
Rozenburglaan 13B
9727 DL Groningen
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Gert Moll (Dr.)
BIOFACTION KG
Austria
EU contribution
€ 374 358
Address
Kundmanngasse 39/12
1030 Wien
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Markus Schmidt (Dr.)