Objective
OBJECTIVE: The ultimate goal of the proposed research is to understand mechanisms involved in limiting the magnitude of the febrile response during infection. A specific aim is to continue a laboratory research on the mechanisms involving epoxygense in controlling fever and inflammation. BACKGROUND: Fever is a neuroimmunomodulatory response mediated by pro-inflammatory cytokines, synthesis of which is activated by bacterial, viral, fungal, and other infectious factors. Principal mechanism of fever involv es a cytokine-provoked liberation of arachidonic acid from cell membranes and induction of cyclooxygenase-2 (COX-2) in cells. Subsequently, COX-2 converts arachidonic acid into prostaglandins. These are molecular events that are also fundamental to the inflammatory processes. JUSTIFICATION: It is well known that exacerbated fever can be harmful.
Clinical data indicate, however, that fever's magnitude very rarely reaches unsafe high measures. But what keeps fever from reaching dangerous heights? The proposer's study initiated in the USA revealed that epoxyeicosanoids, i.e. products of the metabolism of arachidonic acid via epoxygenases (an alternative enzyme system to COX-2), act as endogenous antipyretic and anti-inflammatory factors. Recent data fro m the proposer's laboratory indicate that epoxyeicosanoids reduce the activity of COX-2, which mimics a well-known action of the aspirin-like drugs. These data suggest that epoxyeicosanoids represent a homeostatic mechanism upon inflammation.
An overall hypothesis has been put forward that this endogenous mechanism operates during sickness to set the limits of the immune response, preventing the inflammatory components from reaching a detrimental over-expression. SIGNIFICANCE: A new concept is emerging t hat modulation of this homeostatic process may be included into the current repertoire of prophylaxis, immunotherapy, and treatment of the acute and chronic inflammatory disorders.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences cell biology cell signaling
- natural sciences biological sciences genetics DNA
- natural sciences biological sciences zoology mammalogy
- medical and health sciences basic medicine immunology immunotherapy
- medical and health sciences basic medicine physiology homeostasis
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Programme(s)
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Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2002-MOBILITY-12
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Funding Scheme
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Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
IRG - Marie Curie actions-International re-integration grants
Coordinator
TORUN
Poland
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.