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Single cell genomic profiling of renal cancer stem cells

Objective

"Complex biological systems such as a developing embryo, a regenerating tissue, or a tumor are composed of heterogeneous cell types. The complex behavior of these systems is often dominated by a minority cell population such as the embryonic stem cells in a developing organism or cancer stem cells in tumors. Thus, in order to properly understand development, tissue regeneration, and cancer, a single cell approach must be taken: the biological sample must be ""dissected"" into many individual cells and each single cell has to be characterized independently. In this study we will develop and apply high throughput genomic methods for measuring gene expression in hundreds of individual cells in order to characterize transcriptional heterogeneity in tissues and tumors. This approach will allow us to find unique markers to identify cancer stem cells, elucidate their interactions with other cell types in the tumor, and systematically discover key gene circuits responsible for their long-term survival, self-renewal, and proliferation. As a starting point, we will focus on Wilms’ tumor, which is a common pediatric renal malignancy."

Field of science

  • /medical and health sciences/medical biotechnology/cells technologies/stem cells
  • /medical and health sciences/clinical medicine/oncology/cancer

Call for proposal

FP7-PEOPLE-2013-CIG
See other projects for this call

Funding Scheme

MC-CIG - Support for training and career development of researcher (CIG)

Coordinator

BAR ILAN UNIVERSITY
Address
Bar Ilan University Campus
52900 Ramat Gan
Israel
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 100 000
Administrative Contact
Estelle Waise (Mrs.)