Objective
Skin cancers are the most common types of cancer in the caucasian population, and their incidence has reached epidemic proportions. In addition to skin cancer, inflammatory skin diseases are also extremely common. For the development of novel therapies for skin diseases it is essential to unravel the mechanisms that regulate skin homeostasis and pathological alterations. Recently, the host laboratory made the surprising observation that fibroblast growth factor receptor (FGFR) signalling has a tumor-suppressive function in the epidermis, since loss of FGFR1 and FGFR2 in mouse keratinocytes resulted in the development of skin inflammation, followed by spontaneous formation of carcinomas. The goal of the proposed project is to unravel the mechanisms underlying the functions of FGFRs in the epidermis with a particular focus on micro-RNAs (miRNAs). These small RNAs are emerging as new key players in the regulation of cancer-associated pathways in various tissues. However, FGF-regulated miRNAs in the skin remain to be characterized. FGF-regulated miRNAs and their targets will be identified starting from a combination of miRNA and mRNA profiling of RNA samples from epidermis of control and FGFR mutant mice at different stages of postnatal development and of tumors. Preliminary bioinformatic analysis already identified 5 miRNAs that show significant differences in expression between mutant and control mice. Accordingly, the expression level of more than 300 mRNAs was altered. Based on these data, we will identify those miRNAs that are expressed in keratinocytes in an FGF-dependent manner and we will characterize their functions and the relevant targets in cultured keratinocytes and in normal, inflamed and tumorigenic skin in vivo. Since miRNAs have already been proven to be valuable targets for the treatment of many human diseases, the proposed project has the potential to identify new possible targets for the therapy of major human skin diseases.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine oncology skin cancer
- natural sciences biological sciences genetics RNA
- medical and health sciences basic medicine physiology homeostasis
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2013-IEF
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
8092 Zuerich
Switzerland
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.