Objective Critical biological processes, such as cellular physiology or neuronal transmission have very different spatial scales are due to small binding sites inside or on the cell boundary, or narrow passages between large compartments. The great disparity in spatial scales can be resolved by singular perturbation analysis of their mathematical models. Deriving the function of neuronal synapses from their molecular organization falls precisely in the class of problems associated with diffusion and it constitutes the inherent daunting hurdle of multiple scales. We propose here to construct mathematical models of neuronal microdomains, starting from the molecular to the cellular level and to develop stochastic modeling and singular perturbation methods for asymptotic analysis of the model equations, to use the analytical and numerical approximate solutions to extract properties from newly available molecular data and from Brownian dynamics simulations. A major application of the proposed molecular level modeling is the resolution of the spatiotemporal dynamics regulating neuronal microdomains and synapses. The results of this research will be methods in mathematical modeling, data analysis, asymptotic analysis, and in the designing of stochastic simulations of subcellular processes. Fields of science natural sciencescomputer and information sciencesdata sciencemedical and health sciencesbasic medicinephysiologynatural sciencesmathematicsapplied mathematicsmathematical model Programme(s) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Topic(s) FP7-PEOPLE-2013-IEF - Marie-Curie Action: "Intra-European fellowships for career development" Call for proposal FP7-PEOPLE-2013-IEF See other projects for this call Funding Scheme MC-IEF - Intra-European Fellowships (IEF) Coordinator THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD Address Wellington square university offices OX1 2JD Oxford United Kingdom See on map Region South East (England) Berkshire, Buckinghamshire and Oxfordshire Oxfordshire Activity type Higher or Secondary Education Establishments Administrative Contact Gill Wells (Ms.) Links Contact the organisation Opens in new window Website Opens in new window EU contribution No data
