Objective
Human milk is universally considered as the best nutrition for the new born infant and recent research has revealed that, in addition to its nutritional value, it represents a constant supply of commensal, non-pathogenic and potential probiotic bacteria to the infant gastrointestinal tract. Milk is also a rich source of human milk oligosaccharides (HMOs), which have been shown to interrupt the attachment of enteric pathogens to the intestinal mucosa and to act as prebiotic substrates within the infant intestine, where they can promote the growth of certain beneficial bacteria. Therefore human milk may strongly influence the composition of the new born intestinal microbiota, known to be closely related to survivorship. The rationale behind this multidisciplinary and cooperative project is that human milk composition may have evolved differentially under various environmental pressures. Thus, a single “normal” or healthy milk composition would not exist, but instead it would be conditioned by a combination of evolutionary and socio-ecological factors. The applicant will investigate how selected population-specific factors can contribute to variation of two main human milk components, i.e. HMOs and milk microbiota. In addition, this project will provide further insights on the consequences that these variations may pose to the infant fecal microbiota. To achieve these goals the applicant will use conventional HMOs determination methodologies and will develop a new high-throughput variant of traditional molecular fingerprinting methods, which will significantly improve the existing ability to characterize complex microbial communities. Finally, socioecological data will be collected and analyzed on the studied populations, in order to gain insight on the environmental and evolutionary factors conditioning milk variation. Results obtained will be of great value to the European scientific community and will influence the way “normal” human milk composition is regarded.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences microbiology bacteriology
- medical and health sciences health sciences nutrition
- natural sciences biological sciences ecology ecosystems
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2013-IEF
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
28040 MADRID
Spain
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.