Objective
The aim of this fellowship is to provide the researcher with an advanced, multi-disciplinary training in chondrocyte biology, proteomics and electrophysiology in biomimetic models of osteoarthritis (OA). The challenge will be to investigate the expression, function and regulation of plasma membrane ion channels and calcium signalling pathways of OA chondrocytes by using state of the art proteomic and electrophysiological techniques. OA is one of the leading causes of disability and represents a major healthcare issue in the EU. As no effective treatment is available, there is an urgent need to understand the underlying cellular and molecular mechanisms and develop more targeted therapeutic strategies. Ion channels are important for chondrocyte function and survival; however, the full complement of chondrocyte ion channels (channelome) and their altered expression in OA has yet to be explored. The host organization has already developed and published methods to investigate ion channels of chondrocytes using electrophysiology and proteomics. Nonetheless, comprehensive proteomic studies of the healthy and OA chondrocyte channelome have not been performed. Correlating ion channel expression with altered function and disregulated signalling pathways during the development of OA will provide a better understanding of mechanisms controlling disease progression and will contribute to the understanding of cartilage degeneration. After a preliminary training period, the first stage of the work will involve the exploration of healthy and inflammatory chondrocyte channelomes. The second stage will include the investigation of upstream and downstream calcium dependent and independent signalling pathways that differentially function in OA chondrocytes. The researcher is expected to deliver significant new knowledge and refine current models of OA chondrocyte biology that will benefit the lives of millions of European citizens suffering from this condition.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules proteins proteomics
- natural sciences chemical sciences inorganic chemistry alkaline earth metals
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2013-IEF
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
GU2 7XH Guildford
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.