Objective The major aim of this IVSCP project is the knowledge transfer from the Marie Curie International Incoming Fellow (IIF), Dr. Murdoch with strong expertise in cardiovascular microsurgery and background in effectively phenotyping cardiovascular disease in transgenic mouse models to the EU host organisation – Vascular Biology at Aston University. The area of medical research is geared around the knowledge that pivotal in the development of preeclampsia are changes in anti-angiogenic soluble Flt-1 (sFlt-1) and angiogenic placenta growth factor (PlGF). Therefore to find an answer to the current unmet medical need a better understanding of their regulation in preeclampsia and angiogenesis is required. The research aims will drive the knowledge transfer, these include to (i) Assess glutaredoxin-1 as a therapeutic target of preeclampsia; (ii) identify whether Heme oxgenase 1 and cystathionine-g-lyase regulate sFlt-1 by changes in glutaredoxin-1 to effect in vivo angiogenesis; and (iii) Increase our understanding of PIGF gene regulation and function in the endothelium. Dr. Murdoch will aid knowledge transfer through IVSCP by (i) establishing a new research collaboration with his current institute, Vascular Biology Section, Boston University; (ii) provide in vivo training of angiogenesis models and understanding of redox signalling to PhD students and Post-Doctoral Fellows in the host institute and co-host institutes (University of Birmingham and Exeter); (iii) identify novel redox sensitive targets involved in preeclampsia; (iv) provide lectures/practical to undergraduate and MSc students in the School of Life Science; and (v) organise workshops/forums for the wider ERA. Overall, the proposal intends to impart valuable skills and launch an international collaboration. In addition, this will accelerate scientific output from the Vascular Research team which recently moved to Aston University, to maintain its world-leading reputation in preeclampsia. Fields of science medical and health sciencesclinical medicinesurgerymedical and health sciencesclinical medicineobstetricsmedical and health sciencesclinical medicinecardiologycardiovascular diseases Programme(s) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Topic(s) FP7-PEOPLE-2013-IIF - Marie Curie Action: "International Incoming Fellowships" Call for proposal FP7-PEOPLE-2013-IIF See other projects for this call Funding Scheme MC-IIF - International Incoming Fellowships (IIF) Coordinator ASTON UNIVERSITY Address Aston triangle B4 7ET Birmingham United Kingdom See on map Region West Midlands (England) West Midlands Birmingham Activity type Higher or Secondary Education Establishments Administrative Contact Asif Ahmed (Prof.) Links Contact the organisation Opens in new window Website Opens in new window EU contribution No data
