Objective
"The combination of an organocatalyst and a metal catalyst in a single transformation provides novel reactivity and high control in the creation of new bonds. However, this approach has never been applied to the synthesis of complex natural alkaloids. The aim of DOMDICAS is the development of a novel dual-catalysed asymmetric desymmetrisation methodology and its application to the synthesis of Strychnos alkaloids leuconicines A and B. In the first stage of the proposed research, a dual catalytic system, formed by an organocatalyst and a metal catalyst, will be developed for the construction of the key morphan core of leuconicines. The transformation will be carefully studied in order to obtain optimal reactivity and stereocontrol. The methodology will then be extended to a two-component arylative/vinylative version, which will make the desymmetrisation approach more general and useful. The development of this powerful methodology will be crucial for the proposed synthesis of leuconicines A and B. In the key desymmetrisation step the morphan core of the alkaloids will be constructed and the configuration of 3 of their 4 stereocenters will be established. The proposed synthesis permits the diversification of a common late-stage intermediate to other Strychnos alkaloids. The application of this novel methodology to the total synthesis of bioactive natural products such as leuconicines will provide enough amounts of material for thorough biological studies and would also constitute a milestone for the study of structure-activity relationships. Apart from the impact of the high-quality scientific results expected from this project, DOMDICAS will strongly enhance the future career prospects of the applicant as a mature and independent researcher in the European Research Area."
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2013-IEF
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
OX1 2JD Oxford
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.