Pd(II)-catalyzed direct Csp3-H functionalization of amines: a new platform for the synthesis of privileged molecules

Project Information

HINDAMINE

Grant agreement ID: 627416

Project closed

Start date 1 October 2014

End date 30 September 2016

Funded under

• Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)

Total cost € 221 606,40

EU contribution € 221 606,40

Coordinated by

THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
United Kingdom

Objective

Chemical synthesis, as central science, has a tremendous impact in Society by providing highly valuable compounds as new materials, drugs, sensors or sources of energy. Today, the way we get through those molecules is still a problem to solve. The development of novel methodologies for their efficient and straightforward construction is very relevant for Society, in the short, medium and long term. The last decade has seen the development of a new reactivity concept, taking advantage of the ubiquitous of C-H bond. The direct functionalization of this bond brings forth a more economical and faster way for the derivatization of organic compounds. Consequently, the design of metal catalyzed C-H bond functionalization has become a flourishing area in organic synthesis. This proposal details a design blueprint for palladium catalyzed direct Csp3-H bond functionalization of amines without the presence of any directing group. This will constitute a significant breakthrough in the field of metal catalyzed C-H bond functionalization allowing that “unfunctionalized” molecules become synthetic intermediates in synthesis. To achieve our goal we propose the use of easily accessible cyclic hindered amines as a new versatile platform for the functionalization of Csp3-H bonds. These cyclic cores are easily synthesized from the corresponding ketones and amino alcohols and therefore, after the corresponding functionalization step following by deprotection, we could access to γ-functionalized amino alcohols and β-functionalized ketones. Thus, the same chemical platform would allow us to functionalize two different families of important chemical compounds highlighting the impact that the technology presented in this proposal could have in the organic chemistry field. The work will therefore be multi-stranded, rich and broad and offer an excellent training to the Marie Curie Fellow.

Fields of science

CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques.

• natural sciences › chemical sciences › organic chemistry › ketones
• natural sciences › chemical sciences › inorganic chemistry › transition metals
• engineering and technology › electrical engineering, electronic engineering, information engineering › electronic engineering › sensors
• natural sciences › chemical sciences › organic chemistry › alcohols
• natural sciences › chemical sciences › organic chemistry › amines

Programme(s)

• FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)

Topic(s)

• FP7-PEOPLE-2013-IEF - Marie-Curie Action: "Intra-European fellowships for career development"

Call for proposal

FP7-PEOPLE-2013-IEF
See other projects for this call

Funding Scheme

MC-IEF - Intra-European Fellowships (IEF)

Coordinator

THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE

• EU contribution: € 221 606,40
• Address: TRINITY LANE THE OLD SCHOOLS ; CB2 1TN Cambridge ; United Kingdom
• Region: East of England › East Anglia › Cambridgeshire CC
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Renata Schaeffer (Ms.)
• Total cost: No data