Objective
Isothermal titration calorimetry (ITC) is a powerful biophysical method to study intermolecular interaction that has become widely used due to its technological advances. It enables the determination of all thermodynamical parameters of interaction after a single one-hour experiment. The key step of experimental data analysis is the fitting of obtained data using an appropriate binding model. Unfortunately, the limited set of models offered by manufacturers does not allow the full use of ITC for the study of complex molecular mechanisms of interaction. Recently we faced this problem when trying to investigate tau-tubulin binding. Because of its implication in cancer and neurodegenerative diseases this interaction presents great interest for both European host (CRO2) and my lab. Here I propose to create an advanced ITC data analysis tool that will allow researchers to create and share new binding models, so that any ITC end user can upload their experimental data and fit it using available models. This tool will also offer ITC data management and collaborative facilities. It should become a professional social network for ITC end users in Europe and beyond.
Using this tool, in the host institution, I will first focus on deciphering the exact mechanism of tau-tubulin interaction which, despite extensive study, remains unknown. I will then study the interplay between tau and anticancer drugs. This will allow us to evaluate the impact of anti-tubulin drugs used in cancer treatment on tau mechanism of action. During the return phase I will study the influence of two key factors implicated in neurodegenerative disorders, oxidative stress and zinc ions, on tau-tubulin interaction.
My experience in ITC and multidisciplinary skills combined with the expertise and resources of the host lab will ensure the success of this project. Moreover, new software tool will be made available to other European laboratories, helping establishing CRO2 as one of the leaders in ITC field.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences computer and information sciences data science
- natural sciences computer and information sciences software
- natural sciences chemical sciences inorganic chemistry transition metals
- natural sciences chemical sciences analytical chemistry calorimetry
- medical and health sciences clinical medicine oncology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2013-IIF
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
13284 Marseille
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.