Objective
The aim of this proposal is to develop new and sustainable synthetic methods employing visible light as the sole energy source. MacMillan has demonstrated this concept by merging photoredox catalysis with organocatalytic protocols to perform previously unknown direct enantioselective carbonyl α-functionalization reactions. Building upon this precedent the outgoing phase of this project seeks to incorporate this photoredox process into an organocascade catalysis sequence to generate synthetically valuable intermediates that are relevant in medicinal and natural product chemistry. In this project we propose the merger of iminium ion catalysis with a photoredox-organocatalytic process to generate enantioenriched aldehydes that are α- and β-functionalized from inexpensive and readily available starting materials. This would constitute the first example of an organocascade sequence involving a photoredox system and its compatibility with iminium ion catalysis.
During the return phase photoredox catalysis will be merged with gold chemistry to develop a new methodology for the construction of biaryl systems, which are ubiquitous in pharmaceuticals and organic materials. This protocol will provide a complementary procedure to the Au-catalyzed arylation reaction disclosed by the Lloyd-Jones group, which utilizes arylsilanes as coupling partners. This approach presents a more sustainable approach to biaryl formation that generates less chemical waste and involves readily available starting materials. Overall, the pioneering nature of this proposal as well as the opportunity to forge new international collaborations between two leading research institutions would contribute significantly to scientific excellence in Europe. Moreover, the fellow would develop and gain numerous skills that will ensure his pursuit of an independent research career is prosperous.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences chemical sciences organic chemistry aldehydes
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs
- natural sciences chemical sciences catalysis
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2013-IOF
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
EH8 9YL Edinburgh
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.