Objective
Transaldolases (Tal) catalyse the reversible transfer of an activated dihydroxyacetone moiety from a donor ketose to an acceptor aldose. As they catalyse the formation of two adjacent chiral carbon atoms with strict stereo specificity they are desired tool s in asymmetric synthesis but their use is limited due to their substrate specificity. So approaches are taken to understand and modify the substrate and stereo specificity of transaldolases. To find transaldolases with new properties we made use of the in creasing number of sequences available and discovered two new families of large transaldolases. One family consists of cyanobacterial sequences and the other one of plant sequences. Representatives of both families will be studied with respect to their sub strate and stereo specificity and compared to Tal B from Escherichia coli. Furthermore their three dimensional structure will be determined by X-ray crystallography. The cyanobacterial Tals which contain additional EF-hand motifs will be investigated for t heir capacity to bind Ca2+ and its possible regulatory function. After a training period abroad (3 years as a Ph.D. student at the Eidgenössische Technische Hochschule (ETH) Zürich, Switzerland and 2 years initial Marie Curie Individual Fellowship at the University of Cambridge, UK) Anne Samland is now coming back to her home country Germany. Besides the project proposed here she will be involved in on-going research in the field of C-C bond forming enzymes and their biotechnological application. A new proteomic group for the University will be set up in the institute. She will be responsible as a specialist for protein chromatography and MALDI-TOF mass spectrometry. She will be part of the teaching staff and as such will be supervising students in practical courses and will be involved in lecturing. This will give her the opportunity for re-integration into the German system.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences microbiology bacteriology
- natural sciences earth and related environmental sciences geology mineralogy crystallography
- natural sciences chemical sciences catalysis biocatalysis
- natural sciences chemical sciences analytical chemistry mass spectrometry
- natural sciences biological sciences biochemistry biomolecules proteins enzymes
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2002-MOBILITY-11
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
STUTTGART
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.