Objective beta-catenin/TCF signalling in the intestinal epithelium controls colorectal cancer (CRC) initiation but also Stem Cell maintenance and specification. We have recently shown that paradoxically both processes are driven by the same genetic program. However, recent observations indicate that Wnt signalling might also direct a specific program in tumour cells, and that the core set of beta-catenin/TCF targets shared between CRC cells and intestinal Stem Cells is further modified throughout tumorigenesis. This project aims to the characterization of the beta-catenin/TCF target gene program that specifically drives the process of tumour formation in three steps; first, the identification and characterization of the different programs driven by beta-catenin/TCF in Stem Cells vs. CRC cells. Second, the study of modifications to such programs throughout tumorigenesis and the role of such modifications in tumour progression. Third, the characterization of the interaction between the program driven by beta-catenin/TCF and the TGF-beta pathway and its role in the acquisition of malignancy. New experimental set-ups including gene expression profiling of human tumours in combination with the study of new animal models will be instrumental in answering these questions. I expect that this work will represent a huge step forward in our understanding of the role of Wnt signalling in cancer and its relationship with the processes of Stem Cell maintenance. Fields of science medical and health sciencesmedical biotechnologycells technologiesstem cellsmedical and health sciencesclinical medicineoncologycolorectal cancernatural sciencesbiological sciencesgeneticsmutationmedical and health sciencesbasic medicinepathologynatural sciencesbiological sciencesgeneticsRNA Programme(s) FP6-MOBILITY - Human resources and Mobility in the specific programme for research, technological development and demonstration "Structuring the European Research Area" under the Sixth Framework Programme 2002-2006 Topic(s) MOBILITY-4.1 - Marie Curie European Reintegration Grants (ERG) Call for proposal FP6-2002-MOBILITY-11 See other projects for this call Funding Scheme IIF - Marie Curie actions-Incoming International Fellowships Coordinator PARC CIENTIFIC DE BARCELONA (INSTITUT DE RECERCA BIOMÈDICA DE BARCELONA ) Address Josep samitier 1-5 Barcelona Spain See on map Links Website Opens in new window EU contribution € 0,00
