Objective
The main objective of this proposal is the elucidation of the structure and function of TAF9 proteins and of their potential involvement in Spinal Muscular Atrophy (SMA) pathogenesis. Furthermore, the project is expected to provide useful information on th e organization of the eukaryotic nucleus. If a role of TAF9 proteins as molecular targets for SMA emerged from this project, the structure-function relationship will provide the framework for structure-assisted rational drug design for the treatment of SMA and possibly of other neurodegenerative diseases sharing common features. On an international level, the proposed research activity enhances the synergy between European centres of excellence on a research topic of wide interest, by incorporating collaborations with multiple European laboratories as an essential component. In this vein, the project aspires to initiate both future RTN and RTD Marie Curie actions and collaboration with third-country organisations like the FSMA or the MDA (both USA). On a national level, this project will represent one of the most substantial contributions of Greece to the international research effort to find a cure for SMA. The national significance of the project is underlined by the close collaboration the host institute has with academic organisations and large pharmaceutical companies, like AstraZeneca and Pfizer, thus boosting the academic and industrial competitiveness of Greece and the EU in the biotechnology sector. Another key point of this proposal is to facilitate the establishment of the researcher as an independent investigator. This will be achieved through a well-defined project that combines research methodology in the fields of biochemistry and structural biology, in which the researcher collected experience during his doctoral and postdoctoral training, and of modern molecular biology in which the researcher has specialised during his recent 30-month EU-funded mobility period
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences basic medicine medicinal chemistry
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences biological sciences molecular biology structural biology
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2002-MOBILITY-11
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
ATHENS
Greece
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.