Objective
Pre-eclampsia (PE) complicates 8-10% of pregnancies and represents one of the leading causes of maternal mortality and morbidity. PE is also a major cause of fetal mortality and morbidity, particularly as a result of placental abruption, intra-uterine growth restriction (IUGR) and premature delivery. At present, no early and reliable screening test for PE or IUGR is available. The main objective of this project is to investigate the possibility of combining multiple early pregnancy ultrasound and biochemical markers in order to identify pregnancies at high risk of subsequently developing PE or IUGR. This will involve the assessment of uterine artery flow by Doppler ultrasound, and the determination of multiple maternal serum and urinary markers, in order to identify the best combination of markers to include in a multivariate screening model. The investigations will be repeated at two different gestational intervals in the same unselected pregnant population: 10-14 weeks and 15-18 weeks of gestation. The inno vative approach of the present project is mainly represented by:
a) combining uterine artery assessment and a panel of maternal serum and urine markers. This approach has proved to be extremely successful in screening for other conditions in pregnancy.
b) assessing the screening value of these markers at two gestational intervals in early pregnancy (10-14 weeks and 15-18 weeks), at which stage preventive measures to modify the natural history of the condition are likely to be effective, as opposed to screening tests performed later in pregnancy (from 20 weeks onwards). If successful, the project would therefore be able to provide a reliable early screening tool, and open the way to a series of interventional trials to evaluate the efficacy of the preventive strategies available. In the long term, this may lead to a dramatic reduction of the maternal and fetal/neonatal morbidity and mortality caused by PE and IUGR.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- social sciences sociology demography mortality
- medical and health sciences clinical medicine obstetrics fetal medicine
- engineering and technology medical engineering medical laboratory technology laboratory samples analysis
- medical and health sciences clinical medicine embryology
- natural sciences physical sciences acoustics ultrasound
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2002-MOBILITY-11
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
GENOVA
Italy
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.