Uncovering the Role of Cancer Associated Fibroblasts in Facilitating Breast Cancer Metastasis

Project Information

MetCAF

Grant agreement ID: 637069

DOI 10.3030/637069

Project closed

EC signature date 26 June 2015

Start date 1 July 2015

End date 30 June 2021

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 1 281 958,75

EU contribution € 1 281 958,75

Coordinated by

TEL AVIV UNIVERSITY
Israel

Publications

Peer reviewed articles (7)

Bone metastasis is associated with acquisition of mesenchymal phenotype and immune suppression in a model of spontaneous breast cancer metastasis

Author(s): Lea Monteran, Nour Ershaid, Idan Sabah, Ibrahim Fahoum, Yael Zait, Ophir Shani, Noam Cohen, Anat Eldar-Boock, Ronit Satchi-Fainaro, Neta Erez
Published in: Scientific Reports, Issue 10/1, 2020, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-020-70788-3

Evolution of fibroblasts in the lung metastatic microenvironment is driven by stage-specific transcriptional plasticity

Author(s): Ophir Shani, Yael Raz, Lea Monteran, Ye'ela Scharff, Oshrat Levi-Galibov, Or Megides, Hila Shacham, Noam Cohen, Dana Silverbush, Camilla Avivi, Roded Sharan, Asaf Madi, Ruth Scherz-Shouval, Iris Barshack, Ilan Tsarfaty, Neta Erez
Published in: eLife, Issue 10, 2021, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.60745

Fibroblast-Derived IL33 Facilitates Breast Cancer Metastasis by Modifying the Immune Microenvironment and Driving Type 2 Immunity

Author(s): Ophir Shani, Tatiana Vorobyov, Lea Monteran, Dor Lavie, Noam Cohen, Yael Raz, Galia Tsarfaty, Camila Avivi, Iris Barshack, Neta Erez
Published in: Cancer Research, Issue 80/23, 2020, Page(s) 5317-5329, ISSN 0008-5472
Publisher: American Association for Cancer Research
DOI: 10.1158/0008-5472.can-20-2116

NLRP3 inflammasome in fibroblasts links tissue damage with inflammation in breast cancer progression and metastasis

Author(s): Nour Ershaid, Yoray Sharon, Hila Doron, Yael Raz, Ophir Shani, Noam Cohen, Lea Monteran, Leonor Leider-Trejo, Amir Ben-Shmuel, Muhammad Yassin, Motti Gerlic, Adit Ben-Baruch, Metsada Pasmanik-Chor, Roni Apte, Neta Erez
Published in: Nature Communications, Issue 10/1, 2019, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-019-12370-8

Bone marrow–derived fibroblasts are a functionally distinct stromal cell population in breast cancer

Author(s): Yael Raz, Noam Cohen, Ophir Shani, Rachel E. Bell, Sergey V. Novitskiy, Lilach Abramovitz, Carmit Levy, Michael Milyavsky, Leonor Leider-Trejo, Harold L. Moses, Dan Grisaru, Neta Erez
Published in: The Journal of Experimental Medicine, Issue 215/12, 2018, Page(s) 3075-3093, ISSN 0022-1007
Publisher: Rockefeller University Press
DOI: 10.1084/jem.20180818

The Dark Side of Fibroblasts: Cancer-Associated Fibroblasts as Mediators of Immunosuppression in the Tumor Microenvironment

Author(s): Lea Monteran, Neta Erez
Published in: Frontiers in Immunology, Issue 10, 2019, ISSN 1664-3224
Publisher: Front Immunol
DOI: 10.3389/fimmu.2019.01835

Fibroblasts drive an immunosuppressive and growth-promoting microenvironment in breast cancer via secretion of Chitinase 3-like 1

Author(s): N Cohen, O Shani, Y Raz, Y Sharon, D Hoffman, L Abramovitz, N Erez
Published in: Oncogene, 2017, ISSN 0950-9232
Publisher: Nature Publishing Group
DOI: 10.1038/onc.2017.65

Other (1)

Evolution of metastases-associated fibroblasts in the lung microenvironment is driven by stage-specific transcriptional plasticity

Author(s): Ophir Shani, ProfileYael Raz, Or Megides, Hila Shacham, Noam Cohen, Dana Silverbush, Lea Monteran, Roded Sharan, Ilan Tsarfaty, Neta Erez
Published in: 2019
Publisher: bioRxiv
DOI: 10.1101/778936