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Advanced XFEL and Synchrotron based Probes of Protein Structure and Dynamics

Objective

This cross-disciplinary Marie Curie Innovative Training Network builds upon the transformative opportunities created by existing X-ray sources and new sources soon to be operative in Europe. These opportunities include using ultrafast X-ray sources to extract time-dependent structural information from proteins; and revolutionary possibilities created by X-ray Free Electron Laser radiation for an entirely new regime of pre-damage serial femtosecond crystallography. No lag should exist between building new sources and training the next generation of scientists well versed in using these facilities. Our research training will yield new scientific insights on fundamental properties of protein structure and dynamics: one of the most challenging problems in structural biology; and technological advancements in diverse fields from pharmacology to nanotechnology.
X-probe creates close interdisciplinary collaboration between structural biologists, physical chemists, beamline engineers, software developers, and industrial partners. The rapidly changing state-of-the-art demands that young researchers are trained to meet these new experimental, technical and analysis challenges at the forefront of structural biology and photochemistry. X-probe’s interdisciplinary and intersectorial training network incorporates four leading European X-ray facilities (ESRF, MAXIV Laboratory, European XFEL, SwissFEL); three academic laboratories at the forefront developing X-ray tools to probe protein dynamics; and both large and small industrial partners. Four principal scientists in X-probe are female. X-probe builds close cooperation between traditionally separate fields of research at the very cutting edge of structural biology and creates a visionary training network that would not be possible within any of the individual partner states.

Coordinator

UNIVERSITA DEGLI STUDI DI ROMA LA SAPIENZA
Net EU contribution
€ 258 061,32
Address
Piazzale Aldo Moro 5
00185 Roma
Italy

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Region
Centro (IT) Lazio Roma
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00

Participants (8)

GOETEBORGS UNIVERSITET
Sweden
Net EU contribution
€ 263 659,32
Address
Vasaparken
405 30 Goeteborg

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Region
Södra Sverige Västsverige Västra Götalands län
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
XTAL CONCEPTS GMBH
Germany
Net EU contribution
€ 249 216,48
Address
Schnackenburgallee 13
22525 Hamburg

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Hamburg Hamburg Hamburg
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 0,00
EUROPEAN SYNCHROTRON RADIATION FACILITY
France
Net EU contribution
€ 262 875,60
Address
71 Avenue Des Martyrs
38000 Grenoble

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Region
Auvergne-Rhône-Alpes Rhône-Alpes Isère
Activity type
Research Organisations
Other funding
€ 0,00
UNIVERSITAET HAMBURG
Germany
Net EU contribution
€ 249 216,48
Address
Mittelweg 177
20148 Hamburg

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Region
Hamburg Hamburg Hamburg
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
LUNDS UNIVERSITET
Sweden
Net EU contribution
€ 263 659,32
Address
Paradisgatan 5c
22100 Lund

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Region
Södra Sverige Sydsverige Skåne län
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
MOLIROM SRL
Italy
Net EU contribution
€ 258 061,32
Address
Carlo Bartolomeo Piazza 8
00161 Roma

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Centro (IT) Lazio Roma
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 0,00
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
France
Net EU contribution
€ 262 875,60
Address
Rue Michel Ange 3
75794 Paris

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Region
Ile-de-France Ile-de-France Paris
Activity type
Research Organisations
Other funding
€ 0,00
ASTRAZENECA AB
Sweden
Net EU contribution
€ 263 659,32
Address
Vastra Maelarhamnen
151 85 Sodertaelje

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Region
Östra Sverige Stockholm Stockholms län
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 0,00

Partners (2)

Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

PAUL SCHERRER INSTITUT
Switzerland
Net EU contribution
€ 0,00
Address
Forschungstrasse 111
5232 Villigen Psi

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Region
Schweiz/Suisse/Svizzera Nordwestschweiz Aargau
Activity type
Research Organisations
Other funding
€ 0,00
Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

SAPIENZA INNOVAZIONE CONSORZIO
Italy
Net EU contribution
€ 0,00
Address
Viale Regina Elena 295 Pal Uff Complesso Regina Elena
00161 Roma

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Region
Centro (IT) Lazio Roma
Activity type
Research Organisations
Other funding
€ 0,00