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Advanced XFEL and Synchrotron based Probes of Protein Structure and Dynamics

Objective

This cross-disciplinary Marie Curie Innovative Training Network builds upon the transformative opportunities created by existing X-ray sources and new sources soon to be operative in Europe. These opportunities include using ultrafast X-ray sources to extract time-dependent structural information from proteins; and revolutionary possibilities created by X-ray Free Electron Laser radiation for an entirely new regime of pre-damage serial femtosecond crystallography. No lag should exist between building new sources and training the next generation of scientists well versed in using these facilities. Our research training will yield new scientific insights on fundamental properties of protein structure and dynamics: one of the most challenging problems in structural biology; and technological advancements in diverse fields from pharmacology to nanotechnology.
X-probe creates close interdisciplinary collaboration between structural biologists, physical chemists, beamline engineers, software developers, and industrial partners. The rapidly changing state-of-the-art demands that young researchers are trained to meet these new experimental, technical and analysis challenges at the forefront of structural biology and photochemistry. X-probe’s interdisciplinary and intersectorial training network incorporates four leading European X-ray facilities (ESRF, MAXIV Laboratory, European XFEL, SwissFEL); three academic laboratories at the forefront developing X-ray tools to probe protein dynamics; and both large and small industrial partners. Four principal scientists in X-probe are female. X-probe builds close cooperation between traditionally separate fields of research at the very cutting edge of structural biology and creates a visionary training network that would not be possible within any of the individual partner states.

Field of science

  • /natural sciences/computer and information sciences/data science/data analysis
  • /medical and health sciences/basic medicine/medicinal chemistry
  • /natural sciences/biological sciences/biochemistry/biomolecules/proteins
  • /natural sciences/biological sciences/molecular biology/structural biology
  • /medical and health sciences/basic medicine/pharmacology and pharmacy/drug resistance
  • /natural sciences/computer and information sciences/software/software development
  • /natural sciences/biological sciences/biophysics
  • /natural sciences/earth and related environmental sciences/geology/mineralogy/crystallography
  • /engineering and technology/nanotechnology

Call for proposal

H2020-MSCA-ITN-2014
See other projects for this call

Funding Scheme

MSCA-ITN-ETN - European Training Networks

Coordinator

UNIVERSITA DEGLI STUDI DI ROMA LA SAPIENZA
Address
Piazzale Aldo Moro 5
00185 Roma
Italy
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 258 061,32

Participants (8)

GOETEBORGS UNIVERSITET
Sweden
EU contribution
€ 263 659,32
Address
Vasaparken
405 30 Goeteborg
Activity type
Higher or Secondary Education Establishments
XTAL CONCEPTS GMBH
Germany
EU contribution
€ 249 216,48
Address
Schnackenburgallee 13
22525 Hamburg
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
EUROPEAN SYNCHROTRON RADIATION FACILITY
France
EU contribution
€ 262 875,60
Address
71 Avenue Des Martyrs
38000 Grenoble
Activity type
Research Organisations
UNIVERSITAET HAMBURG
Germany
EU contribution
€ 249 216,48
Address
Mittelweg 177
20148 Hamburg
Activity type
Higher or Secondary Education Establishments
LUNDS UNIVERSITET
Sweden
EU contribution
€ 263 659,32
Address
Paradisgatan 5C
22100 Lund
Activity type
Higher or Secondary Education Establishments
MOLIROM SRL
Italy
EU contribution
€ 258 061,32
Address
Carlo Bartolomeo Piazza 8
00161 Roma
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
France
EU contribution
€ 262 875,60
Address
Rue Michel Ange 3
75794 Paris
Activity type
Research Organisations
ASTRAZENECA AB
Sweden
EU contribution
€ 263 659,32
Address
Vastra Maelarhamnen
151 85 Sodertaelje
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)

Partners (2)

PAUL SCHERRER INSTITUT
Switzerland
Address
Forschungstrasse 111
5232 Villigen Psi
Activity type
Research Organisations
SAPIENZA INNOVAZIONE CONSORZIO
Italy
Address
Viale Regina Elena 295 Pal Uff Complesso Regina Elena
00161 Roma
Activity type
Research Organisations