Identifying pathways of cellular nanoparticle uptake and early processing for novel nanomedicine applications

Project Information

NanoPaths

Grant agreement ID: 637614

DOI 10.3030/637614

Project closed

EC signature date 3 June 2015

Start date 1 July 2015

End date 30 April 2021

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 1 498 746,25

EU contribution € 1 498 746,25

Coordinated by

RIJKSUNIVERSITEIT GRONINGEN
Netherlands

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (18)

Mechanisms of Uptake and Membrane Curvature Generation for the Internalization of Silica Nanoparticles by Cells

Author(s): Valentina Francia, Catharina Reker-Smit, Anna Salvati
Published in: Nano Letters, 2022, ISSN 1530-6992
Publisher: American Chemical Society
DOI: 10.1021/acs.nanolett.2c00537

Comparison of the uptake mechanisms of zwitterionic and negatively charged liposomes by HeLa cells

Author(s): Daphne Montizaan, Keni Yang, Catharina Reker-Smit, Anna Salvati
Published in: Nanomedicine: Nanotechnology, Biology and Medicine, Issue 30, 2020, Page(s) 102300, ISSN 1549-9634
Publisher: Elsevier BV
DOI: 10.1016/j.nano.2020.102300

Time‐ and Space‐Resolved Flow‐Cytometry of Cell Organelles to Quantify Nanoparticle Uptake and Intracellular Trafficking by Cells

Author(s): Hector Garcia Romeu, Sarah Deville, Anna Salvati
Published in: Small, 2021, Page(s) 2100887, ISSN 1613-6810
Publisher: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/smll.202100887

Effect of endothelial cell heterogeneity on nanoparticle uptake

Author(s): Aldy Aliyandi, Simon Satchell, Ronald E. Unger, Birke Bartosch, Romain Parent, Inge S. Zuhorn, Anna Salvati
Published in: International Journal of Pharmaceutics, Issue 587, 2020, Page(s) 119699, ISSN 0378-5173
Publisher: Elsevier BV
DOI: 10.1016/j.ijpharm.2020.119699

Sources of variability in nanoparticle uptake by cells

Author(s): Christoffer Åberg, Valeria Piattelli, Daphne Montizaan, Anna Salvati
Published in: Nanoscale, Issue 13/41, 2021, Page(s) 17530-17546, ISSN 2040-3364
Publisher: Royal Society of Chemistry
DOI: 10.1039/d1nr04690j

Correlating Corona Composition and Cell Uptake to Identify Proteins Affecting Nanoparticle Entry into Endothelial Cells

Author(s): Aldy Aliyandi; Catharina Reker-Smit; Reinier Bron; Inge S. Zuhorn; Anna Salvati
Published in: ACS Biomaterials Science and Engineering, Issue 2, 2021, ISSN 2373-9878
Publisher: American Chemical Society
DOI: 10.1021/acsbiomaterials.1c00804

Effect of the Development of a Cell Barrier on Nanoparticle Uptake in Endothelial Cells

Author(s): Valentina Francia, Aldy Aliyandi, Anna Salvati
Published in: Nanoscale, 2018, ISSN 2040-3364
Publisher: Royal Society of Chemistry
DOI: 10.1039/C8NR03171A

Corona Composition Can Affect the Mechanisms Cells Use to Internalize Nanoparticles

Author(s): Valentina Francia, Keni Yang, Sarah Deville, Catharina Reker-Smit, Inge Nelissen, Anna Salvati
Published in: ACS Nano, Issue 13/10, 2019, Page(s) 11107-11121, ISSN 1936-0851
Publisher: American Chemical Society
DOI: 10.1021/acsnano.9b03824

Limits and challenges in using transport inhibitors to characterize how nano-sized drug carriers enter cells

Author(s): Valentina Francia, Catharina Reker-Smit, Guido Boel, Anna Salvati
Published in: Nanomedicine, Issue 14/12, 2019, Page(s) 1533-1549, ISSN 1743-5889
Publisher: Future Medicine Ltd.
DOI: 10.2217/nnm-2018-0446

Interactions at the cell membrane and pathways of internalization of nano-sized materials for nanomedicine

Author(s): Valentina Francia, Daphne Montizaan, Anna Salvati
Published in: Beilstein Journal of Nanotechnology, Issue 11, 2020, Page(s) 338-353, ISSN 2190-4286
Publisher: Beilstein-Institut Zur Forderung der Chemischen Wissenschaften
DOI: 10.3762/bjnano.11.25

Tuning Liposome Composition to Modulate the Corona Forming in Human Serum and Uptake by Cells

Author(s): Keni Yang, Bárbara Mesquita, Peter Horvatovich, Anna Salvati
Published in: Acta Biomaterialia, 2020, ISSN 1742-7061
Publisher: Elsevier BV
DOI: 10.1016/j.actbio.2020.02.018

Time‐Resolved Quantification of Nanoparticle Uptake, Distribution, and Impact in Precision‐Cut Liver Slices

Author(s): Roberta Bartucci, Christoffer Åberg, Barbro N. Melgert, Ykelien L. Boersma, Peter Olinga, Anna Salvati
Published in: Small, 2020, Page(s) 1906523, ISSN 1613-6810
Publisher: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/smll.201906523

Physiology, pathology and the biomolecular corona: the confounding factors in nanomedicine design

Author(s): Kai Liu, Anna Salvati, Alan Sabirsh
Published in: Nanoscale, 2022, ISSN 2040-3372
Publisher: Royal Society of Chemistry
DOI: 10.1039/d1nr08101b

Light-Triggered Trafficking to the Cell Nucleus of a Cationic Polyamidoamine Functionalized with Ruthenium Complexes

Author(s): Luca Mascheroni, Valentina Francia, Beatrice Rossotti, Elisabetta Ranucci, Paolo Ferruti, Daniela Maggioni, Anna Salvati
Published in: ACS Applied Materials & Interfaces, Issue 12/31, 2020, Page(s) 34576-34587, ISSN 1944-8244
Publisher: American Chemical Society
DOI: 10.1021/acsami.0c08033

Disentangling Biomolecular Corona Interactions With Cell Receptors and Implications for Targeting of Nanomedicines

Author(s): Aldy Aliyandi, Inge S. Zuhorn, Anna Salvati
Published in: Frontiers in Bioengineering and Biotechnology, Issue 8, 2020, ISSN 2296-4185
Publisher: Frontiers Media SA
DOI: 10.3389/fbioe.2020.599454

Imaging of nanoparticle uptake and kinetics of intracellular trafficking in individual cells

Author(s): Natalia Vtyurina, Christoffer Åberg, Anna Salvati
Published in: Nanoscale, Issue 13/23, 2021, Page(s) 10436-10446, ISSN 2040-3364
Publisher: Royal Society of Chemistry
DOI: 10.1039/d1nr00901j

Drug Targeting and Nanomedicine: Lessons Learned from Liver Targeting and Opportunities for Drug Innovation

Author(s): Anna Salvati, Klaas Poelstra
Published in: Pharmaceutics, 2022, ISSN 1999-4923
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics14010217

Effects of Protein Source on Liposome Uptake by Cells: Corona Composition and Impact of the Excess Free Proteins

Author(s): Keni Yang, Catharina Reker‐Smit, Marc C. A. Stuart, Anna Salvati
Published in: Advanced Healthcare Materials, 2021, Page(s) 2100370, ISSN 2192-2640
Publisher: John Wiley and Sons Ltd
DOI: 10.1002/adhm.202100370