Periodic Reporting for period 4 - DE-ORPHAN (DEtermination of Orphan Receptor PHysiological Agonists and sigNals)
Reporting period: 2019-11-01 to 2020-04-30
The main results are:
1. Discovery of physiological peptide hormones for five GPCRs (Foster et al., Cell 2019).
2. Tool compounds for three receptors that can be used to uncover their pharmacology and function.
3. Unique data and webserver tools in our open access database GPCRdb serving >4,000 users/mon.
So far, the project has led to 20 peer-reviewed articles, 15 invited conference talks by the PI and 4 workshops.