Structural Dynamics of Protein Complexes by Solid-State NMR

Project Information

complexNMR

Grant agreement ID: 639907

DOI 10.3030/639907

Project closed

EC signature date 18 March 2015

Start date 1 May 2015

End date 31 October 2020

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 1 999 044,00

EU contribution € 1 999 044,00

Coordinated by

UNIVERSITY OF WARWICK
United Kingdom

Publications

Peer reviewed articles (9)

Solid-State NMR Provides Evidence for Small-Amplitude Slow Domain Motions in a Multispanning Transmembrane α-Helical Protein

Author(s): Daryl Good, Charlie Pham, Jacob Jagas, Józef R. Lewandowski, Vladimir Ladizhansky
Published in: Journal of the American Chemical Society, Issue 139/27, 2017, Page(s) 9246-9258, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.7b03974

Characterization of Protein–Protein Interfaces in Large Complexes by Solid-State NMR Solvent Paramagnetic Relaxation Enhancements

Author(s): Carl Öster, Simone Kosol, Christoph Hartlmüller, Jonathan M. Lamley, Dinu Iuga, Andres Oss, Mai-Liis Org, Kalju Vanatalu, Ago Samoson, Tobias Madl, Józef R. Lewandowski
Published in: Journal of the American Chemical Society, Issue 139/35, 2017, Page(s) 12165-12174, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.7b03875

1 H line width dependence on MAS speed in solid state NMR – Comparison of experiment and simulation

Author(s): Ulrich Sternberg, Raiker Witter, Ilya Kuprov, Jonathan M. Lamley, Andres Oss, Józef R. Lewandowski, Ago Samoson
Published in: Journal of Magnetic Resonance, Issue 291, 2018, Page(s) 32-39, ISSN 1090-7807
Publisher: Academic Press
DOI: 10.1016/j.jmr.2018.04.003

Mechanism of intersubunit ketosynthase–dehydratase interaction in polyketide synthases

Author(s): Matthew Jenner, Simone Kosol, Daniel Griffiths, Panward Prasongpholchai, Lucio Manzi, Andrew S Barrow, John E Moses, Neil J Oldham, Józef R Lewandowski, Gregory L Challis
Published in: Nature Chemical Biology, Issue 14/3, 2018, Page(s) 270-275, ISSN 1552-4450
Publisher: Nature Publishing Group
DOI: 10.1038/nchembio.2549

Intermolecular Interactions and Protein Dynamics by Solid-State NMR Spectroscopy

Author(s): Jonathan M. Lamley, Carl Öster, Rebecca A. Stevens, Józef R. Lewandowski
Published in: Angewandte Chemie International Edition, Issue 54/51, 2015, Page(s) 15374-15378, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201509168

Structural basis for chain release from the enacyloxin polyketide synthase

Author(s): Simone Kosol, Angelo Gallo, Daniel Griffiths, Timothy R. Valentic, Joleen Masschelein, Matthew Jenner, Emmanuel L. C. de los Santos, Lucio Manzi, Paulina K. Sydor, Dean Rea, Shanshan Zhou, Vilmos Fülöp, Neil J. Oldham, Shiou-Chuan Tsai, Gregory L. Challis, Józef R. Lewandowski
Published in: Nature Chemistry, Issue 11/10, 2019, Page(s) 913-923, ISSN 1755-4330
Publisher: Nature Publishing Group
DOI: 10.1038/s41557-019-0335-5

Quantifying Microsecond Exchange in Large Protein Complexes with Accelerated Relaxation Dispersion Experiments in the Solid State

Author(s): Carl Öster, Simone Kosol, Józef R. Lewandowski
Published in: Scientific Reports, Issue 9/1, 2019, Page(s) 1-10, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-019-47507-8

A suite of solid-state NMR experiments to utilize orphaned magnetization for assignment of proteins using parallel high and low gamma detection

Author(s): A. Gallo, W.T. Franks, J.R. Lewandowski
Published in: Journal of Magnetic Resonance, Issue 305, 2019, Page(s) 219-231, ISSN 1090-7807
Publisher: Academic Press
DOI: 10.1016/j.jmr.2019.07.006

Structural studies suggest aggregation as one of the modes of action for teixobactin

Author(s): Carl Öster, Grzegorz P. Walkowiak, Dallas E. Hughes, Amy L. Spoering, Aaron J. Peoples, Anita C. Catherwood, Julie A. Tod, Adrian J. Lloyd, Torsten Herrmann, Kim Lewis, Christopher G. Dowson, Józef R. Lewandowski
Published in: Chemical Science, Issue 9/47, 2018, Page(s) 8850-8859, ISSN 2041-6520
Publisher: Royal Society of Chemistry
DOI: 10.1039/c8sc03655a