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Metabolic and Genetic Regulation of Ageing

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Loss of GFAT-1 feedback regulation activates the hexosamine pathway that modulates protein homeostasis

Author(s): Sabine Ruegenberg, Moritz Horn, Christian Pichlo, Kira Allmeroth, Ulrich Baumann, Martin S. Denzel
Published in: Nature Communications, 11/1, 2020, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-020-14524-5

Hexosamine Pathway Activation Improves Protein Homeostasis through the Integrated Stress Response

Author(s): Moritz Horn, Sarah I. Denzel, Balaji Srinivasan, Kira Allmeroth, Isabelle Schiffer, Vignesh Karthikaisamy, Stephan Miethe, Peter Breuer, Adam Antebi, Martin S. Denzel
Published in: iScience, 23/3, 2020, Page(s) 100887, ISSN 2589-0042
Publisher: Cell Press
DOI: 10.1016/j.isci.2020.100887

Emerging topics in C. elegans aging research: Transcriptional regulation, stress response and epigenetics

Author(s): Martin S. Denzel, Louis R. Lapierre, Hildegard I.D. Mack
Published in: Mechanisms of Ageing and Development, 177, 2019, Page(s) 4-21, ISSN 0047-6374
Publisher: Elsevier BV
DOI: 10.1016/j.mad.2018.08.001

Unbiased compound-protein interface mapping and prediction of chemoresistance loci through forward genetics in haploid stem cells

Author(s): Moritz Horn, Virginia Kroef, Kira Allmeroth, Nicole Schuller, Stephan Miethe, Martin Peifer, Josef M. Penninger, Ulrich Elling, Martin S. Denzel
Published in: Oncotarget, 9/11, 2018, ISSN 1949-2553
Publisher: Impact Journals
DOI: 10.18632/oncotarget.24305

Bortezomib resistance mutations in PSMB5 determine response to second-generation proteasome inhibitors in multiple myeloma

Author(s): Kira Allmeroth, Moritz Horn, Virginia Kroef, Stephan Miethe, Roman-Ulrich Müller, Martin S. Denzel
Published in: Leukemia, 2020, ISSN 0887-6924
Publisher: Nature Publishing Group
DOI: 10.1038/s41375-020-0989-4