Mechanisms of actomyosin-based contractility during cytokinesis

Project Information

ACTOMYO

Grant agreement ID: 640553

DOI 10.3030/640553

Project closed

EC signature date 23 June 2015

Start date 1 July 2015

End date 31 October 2022

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 1 499 988,75

EU contribution € 1 499 988,75

Coordinated by

INSTITUTO DE BIOLOGIA MOLECULAR E CELULAR-IBMC
Portugal

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Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Other (1)

Anillin forms linear structures and facilitates furrow ingression after septin and formin depletion

Author(s): Mikhail Lebedev, Fung-Yi Chan, Jennifer Bellessem, Daniel S. Osório, Elisabeth Rackles, Tamara Mikeladze-Dvali, Ana X. Carvalho, Esther Zanin
Published in: bioRxiv, 2022
Publisher: bioRxiv
DOI: 10.1101/2022.12.22.521621

Peer reviewed articles (15)

Sorting nexin 3 mutation impairs development and neuronal function in Caenorhabditis elegans

Author(s): Neide Vieira, Carlos Bessa, Ana J. Rodrigues, Paulo Marques, Fung-Yi Chan, Ana Xavier de Carvalho, Margarida Correia-Neves, Nuno Sousa
Published in: Cellular and Molecular Life Sciences, Issue 75/11, 2018, Page(s) 2027-2044, ISSN 1420-682X
Publisher: Birkhauser Verlag
DOI: 10.1007/s00018-017-2719-2

Dynactin binding to tyrosinated microtubules promotes centrosome centration in C. elegans by enhancing dynein-mediated organelle transport

Author(s): Daniel J. Barbosa, Joana Duro, Bram Prevo, Dhanya K. Cheerambathur, Ana X. Carvalho, Reto Gassmann
Published in: PLOS Genetics, Issue 13/7, 2017, Page(s) e1006941, ISSN 1553-7404
Publisher: PLOS
DOI: 10.1371/journal.pgen.1006941

NudE regulates dynein at kinetochores but is dispensable for other dynein functions in the C. elegans early embryo

Author(s): Patrícia A. Simões, Ricardo Celestino, Ana X. Carvalho, Reto Gassmann
Published in: Journal of Cell Science, Issue 131/1, 2018, Page(s) jcs212159, ISSN 0021-9533
Publisher: The Company of Biologists Ltd.
DOI: 10.1242/jcs.212159

Molecular mechanism of dynein recruitment to kinetochores by the Rod–Zw10–Zwilch complex and Spindly

Author(s): José B. Gama, Cláudia Pereira, Patrícia A. Simões, Ricardo Celestino, Rita M. Reis, Daniel J. Barbosa, Helena R. Pires, Cátia Carvalho, João Amorim, Ana X. Carvalho, Dhanya K. Cheerambathur, Reto Gassmann
Published in: The Journal of Cell Biology, Issue 216/4, 2017, Page(s) 943-960, ISSN 0021-9525
Publisher: Rockefeller University Press
DOI: 10.1083/jcb.201610108

TPXL-1 activates Aurora A to clear contractile ring components from the polar cortex during cytokinesis

Author(s): Sriyash Mangal, Jennifer Sacher, Taekyung Kim, Daniel Sampaio Osório, Fumio Motegi, Ana Xavier Carvalho, Karen Oegema, Esther Zanin
Published in: The Journal of Cell Biology, Issue 217/3, 2018, Page(s) 837-848, ISSN 0021-9525
Publisher: Rockefeller University Press
DOI: 10.1083/jcb.201706021

Robust gap repair in the contractile ring ensures timely completion of cytokinesis.

Author(s): Silva AM, Osório DS, Pereira AJ, Maiato H, Pinto IM, Rubinstein B, Gassmann R, Telley IA, Carvalho AX.
Published in: JOURNAL OF CELL BIOLOGY, 2016, ISSN 0021-9525
Publisher: Rockefeller University Press
DOI: 10.1083/jcb.201605080

Network Contractility during Cytokinesis—From Molecular to Global Views

Author(s): Joana Leite, Daniel Sampaio Osorio, Ana Filipa Sobral, Ana Marta Silva, Ana Xavier Carvalho
Published in: Biomolecules, Issue 9/5, 2019, Page(s) 194, ISSN 2218-273X
Publisher: MDPI
DOI: 10.3390/biom9050194

Crosslinking activity of non-muscle myosin II is not sufficient for embryonic cytokinesis in C. elegans

Author(s): D. S. Osorio, F. Y. Chan, J. Saramago, J. Leite, A. M. Silva, A. F. Sobral, R. Gassmann, A. X. Carvalho
Published in: Development, 2019, Page(s) dev.179150, ISSN 0950-1991
Publisher: The Company of Biologists Ltd.
DOI: 10.1242/dev.179150

The ARP2/3 complex prevents excessive formin activity during cytokinesis

Author(s): Fung-Yi Chan, Ana M. Silva, Joana Saramago, Joana Pereira-Sousa, Hailey E. Brighton, Marisa Pereira, Karen Oegema, Reto Gassmann, Ana Xavier Carvalho
Published in: Molecular Biology of the Cell, Issue 30/1, 2019, Page(s) 96-107, ISSN 1059-1524
Publisher: American Society for Cell Biology
DOI: 10.1091/mbc.e18-07-0471

Self-Assembly of the RZZ Complex into Filaments Drives Kinetochore Expansion in the Absence of Microtubule Attachment

Author(s): Cláudia Pereira, Rita M. Reis, José B. Gama, Ricardo Celestino, Dhanya K. Cheerambathur, Ana X. Carvalho, Reto Gassmann
Published in: Current Biology, Issue 28/21, 2018, Page(s) 3408-3421.e8, ISSN 0960-9822
Publisher: Cell Press
DOI: 10.1016/j.cub.2018.08.056

A transient helix in the disordered region of dynein light intermediate chain links the motor to structurally diverse adaptors for cargo transport

Author(s): Ricardo Celestino, Morkos A. Henen, José B. Gama, Cátia Carvalho, Maxwell McCabe, Daniel J. Barbosa, Alexandra Born, Parker J. Nichols, Ana X. Carvalho, Reto Gassmann, Beat Vögeli
Published in: PLOS Biology, Issue 17/1, 2019, Page(s) e3000100, ISSN 1545-7885
Publisher: PLOS
DOI: 10.1371/journal.pbio.3000100

PIG-1 MELK-dependent phosphorylation of nonmuscle myosin II promotes apoptosis through CES-1 Snail partitioning

Author(s): Hai Wei, Eric J. Lambie, Daniel S. Osorio, Ana X. Carvalho, Barbara Conradt
Published in: PLoS Genetics, Issue 16(9), 2020, ISSN 1553-7390
Publisher: Public Library of Science
DOI: 10.1371/journal.pgen.1008912

Equatorial Non-muscle Myosin II and Plastin Cooperate to Align and Compact F-actin Bundles in the Cytokinetic Ring

Author(s): Joana Leite, Fung-Yi Chan, Daniel S. Osorio, Joana Saramago, Ana F. Sobral, Ana M. Silva, Reto Gassmann, Ana X. Carvalho
Published in: Frontiers in Cell and Developmental Biology, 2020, ISSN 2296-634X
Publisher: Frontiers Media S.A.
DOI: 10.3389/fcell.2020.573393

β-heavy-spectrin stabilizes the constricting contractile ring during cytokinesis

Author(s): Ana Marta Silva; Fung-Yi Chan; Michael J. Norman; Ana Filipa Sobral; Esther Zanin; Reto Gassmann; Julio Monti Belmonte; Ana Xavier Carvalho
Published in: Journal of Cell Biology, 2022, ISSN 0021-9525
Publisher: Rockefeller University Press
DOI: 10.1083/jcb.202202024

Plastin and spectrin cooperate to stabilize the actomyosin cortex during cytokinesis

Author(s): Ana Filipa Sobral, Fung-Yi Chan, Michael J. Norman, Daniel S. Osorio, Ana Beatriz Dias, Vanessa Ferreira, Daniel J. Barbosa, Dhanya Cheerambathur, Reto Gassmann, Julio Monti Belmonte, Ana Xavier Carvalho
Published in: Current Biology, Issue 31, 2021, Page(s) 1-14, ISSN 0960-9822
Publisher: Cell Press
DOI: 10.1016/j.cub.2021.09.055

Monographic books (1)

Emerging Mechanisms and Roles for Asymmetric Cytokinesis

Author(s): C.Thieleke-Matos, D.S.Osório, A.X.Carvalho, E.Morais-de-Sá
Published in: International Review of Cell and Molecular Biology, 2017
Publisher: Elsevier