Periodic Reporting for period 3 - BetaDropNMR (Ultra-sensitive NMR in liquids)
Reporting period: 2018-10-01 to 2020-03-31
As next steps we plan to measure chemical shifts and relaxation times on G-quadruplex sequences in liquid environment. Then, during the 2-year period with no short-lived isotopes at CERN we will prepare a setup for checking the degree of polarization by fluorescence detection or conventional NMR and will work on laser-polarization schemes for K, Cu or Zn. We will also attempt to record conventional NMR spectra from stable, but hyperpolarized nuclei of these elements (and Na). If the latter works, until the end of the project we will put all efforts to study the interaction of different biomolecules with stable NMR isotopes of those elements with up to 1e5 improved sensitivity compared to conventional NMR, since the radioactive nuclei should be back at CERN only after the end of the project.