Zinc finger gene therapy in the brain for treating Huntington's disease

Project Information

Fingers4Cure

Grant agreement ID: 641232

DOI 10.3030/641232

Project closed

EC signature date 28 January 2015

Start date 1 February 2015

End date 31 July 2016

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 149 995,00

EU contribution € 149 995,00

Coordinated by

IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE
United Kingdom

Publications

Peer reviewed articles (3)

A shared mechanism of muscle wasting in cancer and Huntington’s disease

Author(s): Michal Mielcarek, Mark Isalan
Published in: Clinical and Translational Medicine, Issue 4/1, 2015, ISSN 2001-1326
Publisher: Springer Verlag
DOI: 10.1186/s40169-015-0076-z

Deimmunization for gene therapy: host matching of synthetic zinc finger constructs enables long-term mutant Huntingtin repression in mice

Author(s): Carmen Agustín-Pavón, Michal Mielcarek, Mireia Garriga-Canut, Mark Isalan
Published in: Molecular Neurodegeneration, Issue 11/1, 2016, ISSN 1750-1326
Publisher: BioMed Central
DOI: 10.1186/s13024-016-0128-x

Huntington's disease is a multi-system disorder

Author(s): Michal Mielcarek
Published in: Rare Diseases, Issue 3/1, 2015, Page(s) e1058464, ISSN 2167-5511
Publisher: Taylor & Francis Online
DOI: 10.1080/21675511.2015.1058464

Intellectual Property Rights

Patent (1)

Peptides having zinc finger domains and uses thereof

Application/Publication number: EP 10187818
Date: 2010-10-15