Skip to main content

Epigenetic regulation of endocrine therapy resistance in breast cancer: A systems medicine approach to predict treatment outcome

Objective

The mission of EpiPredict is to train a multidisciplinary cohort of young researchers in a new approach to fully exploit the epigenetics of complex diseases. The 12 early-stage researchers (ESRs) will focus on a narrowly defined case, Tamoxifen-induced resistance in Estrogen Receptor positive (ER+) breast cancer, considering five resistance interacting pathways. Given the frequent Tamoxifen treatment failure, resistance prevention and reversal is an urgent clinical problem that is central in EpiPredict. The EpiPredict intersectorial training programme employs a timely systems medicine approach combining next-generation systematic epigenetic, gene/protein profiling with innovative gene-specific epigenetic interference technologies for iterative computational modelling. Together the ESRs will identify key epigenetic changes underlying Tamoxifen induced resistance. This will provide an important step towards diagnostic markers/tools to predict treatment outcome and response monitoring setting the scene for breast cancer personalized medicine. The fellows will be trained by experts from 6 academic and 2 non-academic beneficiaries and 7 partner organizations (1 academic, 6 non-academic including industrial/socio-public parties) and 5 visiting scientists, from fields ranging from epigenetics to both computation and medicine. Strong involvement of the private sector ensures exploitation of EpiPredict achievements and exposure of the ESRs to an entrepreneurial mindset.
The cohort of supradisciplinary researchers represents a new generation of research leaders equipped to address complex diseases whilst taking personalized patient aspects into consideration. They will be equipped to compete successfully and succeed in their personal careers. EpiPredict will boost academia and pharma/biotech environments, providing extra impulses to drive European translational science, systems medicine, pharmaceutical industry, and Medical ICT offering ample job opportunities.

Coordinator

UNIVERSITEIT VAN AMSTERDAM
Net EU contribution
€ 766 122,84
Address
Spui 21
1012WX Amsterdam
Netherlands

See on map

Region
West-Nederland Noord-Holland Groot-Amsterdam
Activity type
Higher or Secondary Education Establishments
Other funding
€ 766 122,84

Participants (7)

IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE
United Kingdom
Net EU contribution
€ 546 575,76
Address
South Kensington Campus Exhibition Road
SW7 2AZ London

See on map

Region
London Inner London — West Westminster
Activity type
Higher or Secondary Education Establishments
Other funding
€ 546 575,76
DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG
Germany
Net EU contribution
€ 498 432,96
Address
Im Neuenheimer Feld 280
69120 Heidelberg

See on map

Region
Baden-Württemberg Karlsruhe Heidelberg, Stadtkreis
Activity type
Research Organisations
Other funding
€ 498 432,96
UNIVERSITA' DEGLI STUDI DI MILANO-BICOCCA
Italy
Net EU contribution
€ 258 061,32
Address
Piazza Dell'ateneo Nuovo 1
20126 Milano

See on map

Region
Nord-Ovest Lombardia Milano
Activity type
Higher or Secondary Education Establishments
Other funding
€ 258 061,32
ACADEMISCH ZIEKENHUIS GRONINGEN
Netherlands
Net EU contribution
€ 255 374,28
Address
Hanzeplein 1
9713 GZ Groningen

See on map

Region
Noord-Nederland Groningen Overig Groningen
Activity type
Higher or Secondary Education Establishments
Other funding
€ 255 374,28
SZEGEDI BIOLOGIAI KUTATOKOZPONT
Hungary
Net EU contribution
€ 223 913,52
Address
Temesvari Korut 62
6726 Szeged

See on map

Region
Alföld és Észak Dél-Alföld Csongrád
Activity type
Research Organisations
Other funding
€ 223 913,52
Epiontis GmbH
Germany
Net EU contribution
€ 249 216,48
Address
Rudower Chaussee 29
12489 Berlin

See on map

SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Berlin Berlin Berlin
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 249 216,48
CLINICAGENO LIMITED

Participation ended

United Kingdom
Net EU contribution
€ 0,00
Address
Station Approach 11 Coulsdon North
CR5 2NR Coulsdon Surrey
SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
London Outer London — South Croydon
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 0,00

Partners (7)

Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

Synvolux Therapeutics BV
Netherlands
Net EU contribution
€ 0,00
Address
Jh Oortweg 19
2333 CH Leiden

See on map

SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
West-Nederland Zuid-Holland Agglomeratie Leiden en Bollenstreek
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 0,00
Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

STIFTELSEN FRAUNHOFER-CHALMERS CENTRUM FOR INDUSTRIMATEMATIK
Sweden
Net EU contribution
€ 0,00
Address
Chalmers Science Park
41288 Goeteborg

See on map

SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Södra Sverige Västsverige Västra Götalands län
Activity type
Research Organisations
Other funding
€ 0,00
Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

FH JOANNEUM GESELLSCHAFT MBH
Austria
Net EU contribution
€ 0,00
Address
Alte Poststrasse 149
8020 Graz

See on map

Region
Südösterreich Steiermark Graz
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

AHT Management Kft
Hungary
Net EU contribution
€ 0,00
Address

Budapest

See on map

Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 0,00
Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

Rathenau Instituut
Netherlands
Net EU contribution
€ 0,00
Address

Den Haag

See on map

Region
West-Nederland Zuid-Holland Agglomeratie ’s-Gravenhage
Activity type
Research Organisations
Other funding
€ 0,00
Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

Biotecture
Netherlands
Net EU contribution
€ 0,00
Address
Rudolf Dieselstraat 80-hs
1097 AZ Amsterdam

See on map

SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
West-Nederland Noord-Holland Groot-Amsterdam
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 0,00
Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH
Switzerland
Net EU contribution
€ 0,00
Address
Raemistrasse 101
8092 Zuerich

See on map

Region
Schweiz/Suisse/Svizzera Zürich Zürich
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00