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Epigenetic regulation of endocrine therapy resistance in breast cancer: A systems medicine approach to predict treatment outcome

Objective

The mission of EpiPredict is to train a multidisciplinary cohort of young researchers in a new approach to fully exploit the epigenetics of complex diseases. The 12 early-stage researchers (ESRs) will focus on a narrowly defined case, Tamoxifen-induced resistance in Estrogen Receptor positive (ER+) breast cancer, considering five resistance interacting pathways. Given the frequent Tamoxifen treatment failure, resistance prevention and reversal is an urgent clinical problem that is central in EpiPredict. The EpiPredict intersectorial training programme employs a timely systems medicine approach combining next-generation systematic epigenetic, gene/protein profiling with innovative gene-specific epigenetic interference technologies for iterative computational modelling. Together the ESRs will identify key epigenetic changes underlying Tamoxifen induced resistance. This will provide an important step towards diagnostic markers/tools to predict treatment outcome and response monitoring setting the scene for breast cancer personalized medicine. The fellows will be trained by experts from 6 academic and 2 non-academic beneficiaries and 7 partner organizations (1 academic, 6 non-academic including industrial/socio-public parties) and 5 visiting scientists, from fields ranging from epigenetics to both computation and medicine. Strong involvement of the private sector ensures exploitation of EpiPredict achievements and exposure of the ESRs to an entrepreneurial mindset.
The cohort of supradisciplinary researchers represents a new generation of research leaders equipped to address complex diseases whilst taking personalized patient aspects into consideration. They will be equipped to compete successfully and succeed in their personal careers. EpiPredict will boost academia and pharma/biotech environments, providing extra impulses to drive European translational science, systems medicine, pharmaceutical industry, and Medical ICT offering ample job opportunities.

Field of science

  • /medical and health sciences/clinical medicine/oncology/cancer
  • /medical and health sciences/clinical medicine/oncology/cancer/breast cancer

Call for proposal

H2020-MSCA-ITN-2014
See other projects for this call

Funding Scheme

MSCA-ITN-ETN - European Training Networks

Coordinator

UNIVERSITEIT VAN AMSTERDAM
Address
Spui 21
1012WX Amsterdam
Netherlands
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 766 122,84

Participants (7)

IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE
United Kingdom
EU contribution
€ 546 575,76
Address
South Kensington Campus Exhibition Road
SW7 2AZ London
Activity type
Higher or Secondary Education Establishments
DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG
Germany
EU contribution
€ 498 432,96
Address
Im Neuenheimer Feld 280
69120 Heidelberg
Activity type
Research Organisations
UNIVERSITA' DEGLI STUDI DI MILANO-BICOCCA
Italy
EU contribution
€ 258 061,32
Address
Piazza Dell'ateneo Nuovo 1
20126 Milano
Activity type
Higher or Secondary Education Establishments
ACADEMISCH ZIEKENHUIS GRONINGEN
Netherlands
EU contribution
€ 255 374,28
Address
Hanzeplein 1
9713 GZ Groningen
Activity type
Higher or Secondary Education Establishments
SZEGEDI BIOLOGIAI KUTATOKOZPONT
Hungary
EU contribution
€ 223 913,52
Address
Temesvari Korut 62
6726 Szeged
Activity type
Research Organisations
Epiontis GmbH
Germany
EU contribution
€ 249 216,48
Address
Rudower Chaussee 29
12489 Berlin
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
CLINICAGENO LIMITED

Participation ended

United Kingdom
EU contribution
€ 0
Address
Station Approach 11 Coulsdon North
CR5 2NR Coulsdon Surrey
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)

Partners (7)

Synvolux Therapeutics BV
Netherlands
Address
Jh Oortweg 19
2333 CH Leiden
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
STIFTELSEN FRAUNHOFER-CHALMERS CENTRUM FOR INDUSTRIMATEMATIK
Sweden
Address
Chalmers Science Park
41288 Goeteborg
Activity type
Research Organisations
FH JOANNEUM GESELLSCHAFT MBH
Austria
Address
Alte Poststrasse 149
8020 Graz
Activity type
Higher or Secondary Education Establishments
AHT Management Kft
Hungary
Address

Budapest
Activity type
Other
Rathenau Instituut
Netherlands
Address

Amsterdam
Activity type
Other
Biotecture Ltd
Netherlands
Address
Rudolf Dieselstraat 80-Hs
1097 AZ Amsterdam
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH
Switzerland
Address
Raemistrasse 101
8092 Zuerich
Activity type
Higher or Secondary Education Establishments