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European Training Network on Bone Pain

Objective

The aim is to create an innovative European PhD training network in bone pain. Millions in Europe and beyond suffer from bone pain, a debilitating complication of many musculoskeletal disorders such as arthritis and bone metastasis. However, being a truly multidisciplinary subject spanning neuroscience, bone biology, and even cancer research, it demands a multidisciplinary approach. Despite a huge negative impact on the quality of life of the patients and on society as a whole, no specific treatment is available. To address this societal challenge and the strong innovation potential, we want to form the first European platform to promote frontline research, innovation and education within bone pain. The network encompasses 5 academic and 2 industrial beneficiaries and 1 industrial partner all committed to creating an outstanding wide-ranging yet integrated training program for early stages researchers to elucidate the mechanisms of bone pain and develop new medicines. We will use in vivo models of arthritic pain, cancer-induced bone pain and fracture pain to investigate the pathophysiology and novel treatment strategies. In vivo electrophysiology will be used for studying the physiology and pharmacology of pain transmission and its modulation. Transgenic mouse models will be used to tease out the specific neuronal receptor subtypes involved. Sophisticated behaviour tests will evaluate response to novel treatments. We will create a biobank of human cancer-infiltrated bone to identify specific patterns of neuronal receptor expression and to validate therapeutic targets in humans. In an extensive training effort covering both specific research skills and transferable skills, the students will obtain an interdisciplinary, state-of-the-art and innovative training from the participants, several of which have experience from international networks. The students will benefit from secondments with industrial partners and with some of the foremost pain researchers in Europe

Field of science

  • /medical and health sciences/basic medicine/physiology/pathophysiology
  • /medical and health sciences/clinical medicine/oncology/cancer
  • /medical and health sciences/basic medicine/pharmacology and pharmacy
  • /natural sciences/biological sciences/neurobiology
  • /medical and health sciences/basic medicine/physiology
  • /natural sciences/biological sciences/neurobiology/neuroscience

Call for proposal

H2020-MSCA-ITN-2014
See other projects for this call

Funding Scheme

MSCA-ITN-ETN - European Training Networks

Coordinator

KOBENHAVNS UNIVERSITET
Address
Norregade 10
1165 Kobenhavn
Denmark
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 580 163,76

Participants (6)

UNIVERSITY COLLEGE LONDON
United Kingdom
EU contribution
€ 819 863,64
Address
Gower Street
WC1E 6BT London
Activity type
Higher or Secondary Education Establishments
KAROLINSKA INSTITUTET
Sweden
EU contribution
€ 527 318,64
Address
Nobels Vag 5
17177 Stockholm
Activity type
Higher or Secondary Education Establishments
THE ROYAL VETERINARY COLLEGE
United Kingdom
EU contribution
€ 546 575,76
Address
Royal College Street
NW1 OTU London
Activity type
Higher or Secondary Education Establishments
UNIVERSITAIR MEDISCH CENTRUM UTRECHT
Netherlands
EU contribution
€ 255 374,28
Address
Heidelberglaan 100
3584 CX Utrecht
Activity type
Higher or Secondary Education Establishments
NORDIC BIOSCIENCE A/S
Denmark
EU contribution
€ 580 163,76
Address
Herlev Hovedgade 205-207
2730 Herlev
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
GRUNENTHAL GMBH
Germany
EU contribution
€ 249 216,48
Address
Zieglerstrasse 6
52078 Aachen
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)

Partners (1)

TRANSPHARMATION LTD
United Kingdom
Address
The London Bioscience Innovation Centre 2 Royal College Street
NW1 0NH London
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)