Objective
The cell nucleus is organized and compartmentalized into a highly ordered structure that contains DNA, RNA, chromosomal and histone proteins which make up a structure called chromatin. The dynamics associated with these various components are responsible for regulating physiological processes and the overall stability of the genome. The destabilization of such regulatory mechanisms that act on the chromatin structure are implicated in pathologies such as cancer. Higher order organization of chromatin results in chromosomes which occupy discrete territories within the cell nucleus. Most nuclear processes occur or at least being initiated onto the chromosomes which makes them the main organizing factors in the nucleus. Several proteins that are involved in the replication of DNA, gene transcription and the processing of RNA are found enriched in discrete focal structures. An emerging question is how these structures assemble and are maintained in the absence of membranes and moreover what are the kinetics of stable binding and/or rapid exchange of their components. The dynamic assembly and modification of chromatin during developmental processes as well as the deregulation of such chromatin dynamics during the onset of disease lacks mechanistic insights at present. To address these questions we have put forward a multidisciplinary approach which involves molecular, cellular and systems level approaches by assembling a group of scientists from academia and industry with cross disciplinary expertise and capabilities.
Fields of science
Programme(s)
Funding Scheme
MSCA-ITN-ETN - European Training NetworksCoordinator
70013 Irakleio
Greece
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Participants (12)
80539 MUNCHEN
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16672 Vari-Athens
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16163 Genova
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EH8 9YL Edinburgh
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08908 L'Hospitalet De Llobregat
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17177 Stockholm
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7610001 Rehovot
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4102 Seraing
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
4032 DEBRECEN
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
30659 Hannover
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
KA6 5HW Ayr
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
20121 Milano
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Partners (4)
Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
2950 VEDBAEK
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
12163 Berlin
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
1017BT Amsterdam
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
12163 Berlin
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.