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TBVAC2020; Advancing novel and promising TB vaccine candidates from discovery to preclinical and early clinical development

Objective

The TBVAC2020 proposal builds on the highly successful and long-standing collaborations in subsequent EC-FP5-, FP6- and FP7-funded TB vaccine and biomarker projects, but also brings in a large number of new key partners from excellent laboratories from Europe, USA, Asia, Africa and Australia, many of which are global leaders in the TB field. This was initiated by launching an open call for Expressions of Interest (EoI) prior to this application and to which interested parties could respond. In total, 115 EoIs were received and ranked by the TBVI Steering Committee using proposed H2020 evaluation criteria. This led to the prioritisation of 52 R&D approaches included in this proposal.
TBVAC2020 aims to innovate and diversify the current TB vaccine and biomarker pipeline while at the same time applying portfolio management using gating and priority setting criteria to select as early as possible the most promising TB vaccine candidates, and accelerate their development. TBVAC2020 proposes to achieve this by combining creative “bottom-up” approaches for vaccine discovery (WP1), new preclinical models addressing clinical challenges (WP2) and identification and characterisation of correlates of protection (WP5) with a directive “top-down” portfolio management approach aiming to select the most promising TB vaccine candidates by their comparative evaluation using objective gating and priority setting criteria (WP6) and by supporting direct, head-to head or comparative preclinical and early clinical evaluation (WP3, WP4). This approach will both innovate and diversify the existing TB vaccine and biomarker pipeline as well as accelerate development of most promising TB vaccine candidates through early development stages. The proposed approach and involvement of many internationally leading groups in the TB vaccine and biomarker area in TBVAC2020 fully aligns with the Global TB Vaccine Partnerships (GTBVP).

Call for proposal

H2020-PHC-2014-2015

See other projects for this call

Sub call

H2020-PHC-2014-single-stage

Coordinator

STICHTING TUBERCULOSIS VACCINE INITIATIVE
Net EU contribution
€ 2 473 986,45
Address
Runderweg 6
8219 PK Lelystad
Netherlands
Activity type
Other
Non-EU contribution
€ 0,00

Participants (46)

STATENS SERUM INSTITUT
Denmark
Net EU contribution
€ 1 586 952,00
Address
Artillerivej 5
2300 Kobenhavn S
Activity type
Research Organisations
Non-EU contribution
€ 0,50
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
Germany
Net EU contribution
€ 957 480,00
Address
Hofgartenstrasse 8
80539 Munchen
Activity type
Research Organisations
Non-EU contribution
€ 0,00
ASTON UNIVERSITY

Participation ended

United Kingdom
Net EU contribution
€ 0,00
Address
Aston Triangle
B4 7ET Birmingham
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
Region
West Midlands (England) West Midlands Birmingham
SCIENSANO
Belgium
Net EU contribution
€ 111 864,00
Address
Juliette Wytsmanstraat 14
1050 Elsene
Activity type
Research Organisations
Non-EU contribution
€ 6 136,00
Region
Arr. de Bruxelles-Capitale/Arr. Brussel-Hoofdstad Région de Bruxelles-Capitale/ Brussels Hoofdstedelijk Gewest
UNIVERSITEIT GENT
Belgium
Net EU contribution
€ 23 700,00
Address
Sint Pietersnieuwstraat 25
9000 Gent
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
Region
Vlaams Gewest Prov. Oost-Vlaanderen Arr. Gent
BANGOR UNIVERSITY
United Kingdom
Net EU contribution
€ 23 700,00
Address
College Road
LL57 2DG Bangor
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
UNIVERSITAET ULM
Germany
Net EU contribution
€ 604 824,00
Address
Helmholtzstrasse 16
89081 Ulm
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,38
INSTITUT PASTEUR
France
Net EU contribution
€ 528 980,00
Address
Rue Du Docteur Roux 25-28
75724 Paris Cedex 15
Activity type
Research Organisations
Non-EU contribution
€ 0,00
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
France
Net EU contribution
€ 1 429 056,75
Address
Rue Michel Ange 3
75794 Paris
Activity type
Research Organisations
Non-EU contribution
€ 0,00
Third-party

Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.

UNIVERSITE PAUL SABATIER TOULOUSE III
France
Net EU contribution
€ 285 456,25
Address
Route De Narbonne 118
31062 Toulouse Cedex 9
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
UNIVERSIDAD DE ZARAGOZA
Spain
Net EU contribution
€ 951 792,00
Address
Calle Pedro Cerbuna 12
50009 Zaragoza
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
UNIVERSITE DE GENEVE
Switzerland
Net EU contribution
€ 0,00
Address
Rue Du General Dufour 24
1211 Geneve
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 450 000,00
Region
Schweiz/Suisse/Svizzera Région lémanique Genève
EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH
Switzerland
Net EU contribution
€ 0,00
Address
Raemistrasse 101
8092 Zuerich
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 350 000,00
UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN
Ireland
Net EU contribution
€ 220 030,80
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
YONSEI UNIVERSITY
South Korea
Net EU contribution
€ 0,00
Address
50 Yonsei Ro Seodaemun Gu
120 749 Seoul
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 416 250,00
STICHTING BIOMEDICAL PRIMATE RESEARCH CENTER
Netherlands
Net EU contribution
€ 918 194,88
Address
Lange Kleiweg 161
2288 GJ Rijswijk Zh
Activity type
Research Organisations
Non-EU contribution
€ 537 112,62
Region
West-Nederland Zuid-Holland Agglomeratie ’s-Gravenhage
Department of Health
United Kingdom
Net EU contribution
€ 1 416 150,84
Address
Quarry House, Quarry Hill
LS2 7UE Leeds
Activity type
Research Organisations
Non-EU contribution
€ 168 831,66
Region
Yorkshire and the Humber West Yorkshire Leeds
UNIVERSITAT ZURICH
Switzerland
Net EU contribution
€ 0,00
Address
Ramistrasse 71
8006 Zurich
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 781 262,50
INSTITUT DE INVESTIGACIO EN CIENCIES DE LA SALUT GERMANS TRIAS I PUJOL
Spain
Net EU contribution
€ 415 224,00
Address
Ctra De Canyet S/n
08916 Badalona Barcelona
Activity type
Research Organisations
Non-EU contribution
€ 0,00
UNITED KINGDOM RESEARCH AND INNOVATION
United Kingdom
Net EU contribution
€ 396 294,34
Address
Polaris House North Star Avenue
SN2 1FL Swindon
Activity type
Research Organisations
Non-EU contribution
€ 9 462,66
Region
South West (England) Gloucestershire, Wiltshire and Bristol/Bath area Swindon
STELLENBOSCH UNIVERSITY
South Africa
Net EU contribution
€ 284 400,00
Address
Victoria Street Administration B Building
7600 Stellenbosch
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
UNIVERSITY OF CAPE TOWN
South Africa
Net EU contribution
€ 355 500,00
Address
Private Bag X3
7701 Rondebosch
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE ROYAL CHARTER
United Kingdom
Net EU contribution
€ 1 194 647,50
Address
Keppel Street
WC1E 7HT London
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
Region
London Inner London — West Camden and City of London
AZIENDA OSPEDALIERA UNIVERSITARIA POLICLINICO PAOLO GIACCONE DI PALERMO
Italy
Net EU contribution
€ 118 500,00
Address
Via Del Vespro 129
90127 Palermo
Activity type
Research Organisations
Non-EU contribution
€ 0,00
IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE
United Kingdom
Net EU contribution
€ 308 100,00
Address
South Kensington Campus Exhibition Road
SW7 2AZ London
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
ACADEMISCH ZIEKENHUIS LEIDEN
Netherlands
Net EU contribution
€ 936 937,93
Address
Albinusdreef 2
2333 ZA Leiden
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 1 250,01
Region
West-Nederland Zuid-Holland Agglomeratie Leiden en Bollenstreek
UNIVERSITE LIBRE DE BRUXELLES
Belgium
Net EU contribution
€ 218 040,00
Address
Avenue Franklin Roosevelt 50
1050 Bruxelles
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
Region
Arr. de Bruxelles-Capitale/Arr. Brussel-Hoofdstad Région de Bruxelles-Capitale/ Brussels Hoofdstedelijk Gewest
ISTITUTO NAZIONALE PER LE MALATTIE INFETTIVE LAZZARO SPALLANZANI-ISTITUTO DI RICOVERO E CURA A CARATTERE SCIENTIFICO
Italy
Net EU contribution
€ 218 040,00
Address
Via Portuense, 292
00149 Roma
Activity type
Research Organisations
Non-EU contribution
€ 0,00
THE UNIVERSITY OF SYDNEY
Australia
Net EU contribution
€ 0,00
Address
Camperdown Campus Arundel St 71/79
2006 Sydney
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 133 392,50
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
United Kingdom
Net EU contribution
€ 755 642,50
Address
Wellington Square University Offices
OX1 2JD Oxford
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
Region
South East (England) Berkshire, Buckinghamshire and Oxfordshire Oxfordshire
BUNDESINSTITUT FUR IMPFSTOFFE UND BIOMEDIZINISCHE ARZNEIMITTEL

Participation ended

Germany
Net EU contribution
€ 0,00
Address
Paul-ehrlich-strasse 51-59
63225 Langen
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Non-EU contribution
€ 142 200,00
THE SECRETARY OF STATE FOR ENVIRONMENT, FOOD AND RURAL AFFAIRS
United Kingdom
Net EU contribution
€ 252 686,56
Address
Area 1A, Nobel House, Smith Square 17
SW1P 3JR London
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Non-EU contribution
€ 0,00
KWAZULU NATAL RESEARCH INSTITUTE FOR TB-HIV (K-RITH) NPC
South Africa
Net EU contribution
€ 167 227,20
Address
719 Numbilo Road
4001 Durban
Activity type
Other
Non-EU contribution
€ 0,00
CENTRE HOSPITALIER UNIVERSITAIRE VAUDOIS
Switzerland
Net EU contribution
€ 0,00
Address
Rue Du Bugnon 21
1011 Lausanne
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Non-EU contribution
€ 1 575 000,00
Region
Schweiz/Suisse/Svizzera Région lémanique Vaud
INSTITUT PASTEUR DE LILLE FONDATION
France
Net EU contribution
€ 538 463,99
Address
Rue Du Professeur Calmette 1
59019 Lille
Activity type
Research Organisations
Non-EU contribution
€ 42 033,51
Third-party

Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France
Net EU contribution
€ 0,01
Address
Rue De Tolbiac 101
75654 Paris
Activity type
Research Organisations
Non-EU contribution
€ 36 891,24
UNIVERSITE DE LAUSANNE
Switzerland
Net EU contribution
€ 0,00
Address
Quartier Unil-centre Bâtiment Unicentre
1015 Lausanne
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 745 096,25
Region
Schweiz/Suisse/Svizzera Région lémanique Vaud
UNIVERSITAT BASEL
Switzerland
Net EU contribution
€ 0,00
Address
Petersplatz 1
4051 Basel
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 230 000,00
Region
Schweiz/Suisse/Svizzera Nordwestschweiz Basel-Stadt
Third-party

Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.

UNIVERSITATSSPITAL BASEL
Switzerland
Net EU contribution
€ 0,00
Address
Hebelstrasse 32
4031 Basel
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Non-EU contribution
€ 562 500,00
Region
Schweiz/Suisse/Svizzera Nordwestschweiz Basel-Stadt
ISTITUTO SUPERIORE DI SANITA
Italy
Net EU contribution
€ 206 664,00
Address
Viale Regina Elena 299
00161 Roma
Activity type
Research Organisations
Non-EU contribution
€ 0,00
AERAS GLOBAL TB VACCINE FOUNDATION
United States
Net EU contribution
€ 0,00
Address
Research Boulevard 1405
20850 Rockville Md
Activity type
Research Organisations
Non-EU contribution
€ 50 000,00
INTERNATIONAL TUBERCULOSIS RESEARCH CENTER
South Korea
Net EU contribution
€ 0,00
Address
236 Gaposunhwan Ro Masanhappo Gu Chang Won Si
631 320 Gyeongsangnam Do
Activity type
Research Organisations
Non-EU contribution
€ 425 000,00
GLAXOSMITHKLINE BIOLOGICALS SA
Belgium
Net EU contribution
€ 0,00
Address
Rue De L Institut 89
1330 Rixensart
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 146 300,00
Region
Région wallonne Prov. Brabant Wallon Arr. Nivelles
TRANSGENE SA
France
Net EU contribution
€ 0,00
Address
Boulevard Gonthier D Andernach Parc D Innovation
67400 Illkirch-graffenstaden
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 47 787,50
FRIEDRICH LOEFFLER INSTITUT - BUNDESFORSCHUNGSINSTITUT FUER TIERGESUNDHEIT
Germany
Net EU contribution
€ 142 200,00
Address
Sudufer 10
17493 Greifswald-insel Riems
Activity type
Research Organisations
Non-EU contribution
€ 0,00
Region
Mecklenburg-Vorpommern Mecklenburg-Vorpommern Vorpommern-Greifswald
UNIVERSITY OF STRATHCLYDE
United Kingdom
Net EU contribution
€ 159 264,00
Address
Richmond Street 16
G1 1XQ Glasgow
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00