Repair of tissue and organ damage in refractory chronic graft versus host disease after hematopoietic stem cell transplantation by the infusion of purified allogeneic donor regulatory T lymphocytes

Project Information

TREGeneration

Grant agreement ID: 643776

DOI

10.3030/643776

Project closed

EC signature date 1 December 2014

Start date 1 January 2015

End date 31 December 2021

Funded under

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Total cost

€ 5 899 250,00

EU contribution

€ 5 899 250,00

Coordinated by

INSTITUTO DE MEDICINA MOLECULAR JOAO LOBO ANTUNES
Portugal

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Deliverables

Websites, patent fillings, videos etc. (4)

Individualized press release for every partner
Development of the project logo
Launch of website
Twitter, Facebook, LinkedIn, Account Setup

Documents, reports (1)

Report on the status of the posting of results to the study registry

Publications

Conference proceedings (1)

Phase I/II Clinical Trials of Donor-Derived Purified Regulatory T Cells for the Treatment of Steroid-Refractory Chronic Graft Versus Host Disease

Author(s): Maria VD Soares, Virginia Escamilla Gomez, Rita I Azevedo, Paulo N.G. Pereira, Teresa Caballero Velázquez, Clara B. Garcia-Calderón, Kukatharmini Tharmaratnam, Inês A Cabral, Ana C Ribeiro, Laura Mendes, Clara Juncal, Susana Roncon, Ana Teresa Pais, Ana C Alho, Alfonso Rodriguez Gil, Eduardo L Espada, Anabela Rodrigues, Ana Garção, Marie-Laure Yaspo, Hans-Jörg Warnatz, Hans Lehrach, Nuno L.
Published in: Issue Blood (2022) 140 (Supplement 1), 2022, Page(s) 880–882.
Publisher: The American Society of Hematology
DOI: 10.1182/blood-2022-163394

Peer reviewed articles (2)

High proportion of terminally differentiated regulatory T cells after allogeneic hematopoietic stem cell transplantation.

Author(s): Caroline Ritacco; Grégory Ehx; Céline Gregoire; Coline Daulne; Evelyne Willems; Sophie Servais; Yves Beguin; Frédéric Baron
Published in: Journal, Issue 2, 2021, ISSN 0268-3369
Publisher: Nature Publishing Group
DOI: 10.1038/s41409-021-01221-0

Efficient treatment of murine acute GvHD by in vitro expanded donor regulatory T cells

Author(s): Riegel, Christin; Boeld, Tina J.; Doser, Kristina; Huber, Elisabeth; Hoffmann, Petra; Edinger, Matthias
Published in: Leukemia, Issue 1, 2019, ISSN 0887-6924
Publisher: Nature Publishing Group
DOI: 10.1038/s41375-019-0625-3