Periodic Reporting for period 2 - MEDILIGHT (Miniaturized smart system for light stimulation and monitoring of wound healing)
Reporting period: 2016-08-01 to 2018-07-31
The Consortium has built an innovative flex LED foil with dimensions of 6cmx15cm. The foil is equipped with LEDs and temperature and oxygenation sensors, which is inserted over the wound dressing for the implementation of the light therapy. In addition, new wound dressing for wound healing has been developed and manufactured whereas for bacteria treatment a new dressing has also been found. Advanced heat management solutions have been found to ensure that during the treatment the foil temperature remains under 40oC. An advanced PCB electronic module with modern encasement has been manufactured, housing also a rechargeable battery. A very robust interconnection has been also built between the flex foil and the electronic module via a molded male interconnector. The final MEDILIGHT device (flex foil & electronic module) is friendly and comfortable for the users. The Consortium has also developed light schemes and optimized the light therapies at both wound healing and antibacterial modes. Results have been obtained in-vitro and also confirmation studies have been successfully performed in-vivo. The capture, processing, analysis and storage of sensitive sensor data (temperature and oxygenation) have been demonstrated with the development of embedded software as well the development of brand new smartphone host application tailored to URGO’s expert system which enables diverse functions, among those, advanced oxygenation wound mapping, wound history retrieval, selection of recommended light therapy etc.
• Flex foil manufacturing processes have been defined and implemented. Many flex foils have been manufactured.
• An advanced sensory system has been developed consisted of 5 temperature sensors and 4 oxygenation sensors. The temperature sensors and pulse oximeters have been successfully integrated into the LED foil.
• Tests were carried out using the foils to measure temperature and the red /infrared energy from the pulse oximeters.
• The pulse oximetry sensors on the flex foil, which are multiple sensors with independently controlled LEDs, have been successfully tested. The pulse oximetry mapping concept has shown very positive results.
• The MEDILIGHT electronic module has been designed to incorporate all electronics and a robust connector for the flex foil. Encasement designs after iterations have been finalised to accommodate module PCB and friendly user buttons.
• Software libraries/functions have been implemented to mitigate the risk of the LED array overheating, to perform pulse oximetry mapping measurements and to monitor the battery status.
• Communication with the smartphone device has been successfully implemented. Smartphone host application was tailored to URGO’s expert system.
• The whole MEDILIGHT device is functional
• Further results (Cell counting, BrdU-ELISA, BrdU-FACS) were obtained confirming the XTT results
• Blue light does not stimulate melanoma cell growth
• Temperature maximum was set to 40 °C
• The diffusor was excluded from the stack
• Efficacy of the MEDILIGHT prototypes was proven in vitro
• No cytotoxicity of MEDILIGHT device was confirmed
• Tolerance and efficiency study results showed a tendency of rats treated with MEDILIGHT full device to heal faster
• 2 patent applications have been submitted and a three-point exploitation plan proposed