Skip to main content

Preclinical Intra-Operative Image-Guided Surgery and Post-Operative Radiotherapy of Tumours

Objective

The main objective and basic concept of our proposal is to improve intra-operative and post-operative targeted surgical probes and new detection systems for surgical intervention of cancer. The work revolves around the mobility of clinicians, scientists and technologists between twelve consortium partners and across four different countries. The goal is the implementation of inter-disciplinary, inter-sector, cross-training of personnel. As a consequence, this will serve to accelerate the development of improved imaging technologies and hybrid fluorescence/radionuclide probes for the surgical intervention of cancer. The hypothesis is that if we can develop a hybrid probe for both targeted image-guided surgery and post-operative molecular radiotherapy, we would be implementing a revolutionary imaging and therapeutic approach for oncology surgeons to help their patients by improving better overall survival and quality of life for the patient. There are four key objectives within this project: 1) synthesis of a near infra-red fluorescence (NIRF)-dye conjugated to a peptide that is targeted towards a tumour associated antigen, 2) deliver a novel clinical optoacoustic handheld camera to detect the fluorescence probe in deep tissue, 3) validate the probe/target combination across the subcellular, cellular, endoscopic and macroscopic levels with state-of-art technologies, and 4) develop the probe further by targeting a radionuclide entity to the fluorescent construct for postoperative radiotherapy. Surgeons would have a more definitive reference for resection, if the tumour margin can be clearly defined. If this can be achieved, the impact would be (a) reduced recurrence rates in patients by lowering the risk of residual tumour tissue remaining after surgery and as a consequence improve survival, (b) minimised removal of healthy tissues, c) reduced patient morbidity and hospital stay and d) significant health cost benefits.

Call for proposal

H2020-MSCA-RISE-2014
See other projects for this call

Coordinator

PERCUROS BV
Address
Eerbeeklaan 42
2573 HT 'S-gravenhage
Netherlands
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
EU contribution
€ 378 000

Participants (13)

ACADEMISCH ZIEKENHUIS LEIDEN
Netherlands
EU contribution
€ 486 000
Address
Albinusdreef 2
2333 ZA Leiden
Activity type
Higher or Secondary Education Establishments
UNIVERSITAETSMEDIZIN GOETTINGEN - GEORG-AUGUST-UNIVERSITAET GOETTINGEN - STIFTUNG OEFFENTLICHEN RECHTS
Germany
EU contribution
€ 243 000
Address
Robert-koch-strasse 40
37075 Goettingen
Activity type
Higher or Secondary Education Establishments
UNIVERSITEIT MAASTRICHT
Netherlands
EU contribution
€ 162 000
Address
Minderbroedersberg 4
6200 MD Maastricht
Activity type
Higher or Secondary Education Establishments
ITHERA MEDICAL GMBH
Germany
EU contribution
€ 54 000
Address
Zielstattstrasse 13
81379 Munchen
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
TAGWORKS PHARMACEUTICALS BV
Netherlands
EU contribution
€ 108 000
Address
Vondellaan 11
5611 NX Eindhoven
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
RAYFOS LTD
United Kingdom
EU contribution
€ 216 000
Address
Winton House Winton Square
RG21 8EN Basingstoke
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
TECHNISCHE UNIVERSITAET MUENCHEN
Germany
EU contribution
€ 189 000
Address
Arcisstrasse 21
80333 Muenchen
Activity type
Higher or Secondary Education Establishments
MAUNA KEA TECHNOLOGIES
France
EU contribution
€ 108 000
Address
10 Rue D'enghien
75010 Paris
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
GAMMA TECHNOLOGIES LIMITED

Participation ended

United Kingdom
EU contribution
€ 162 000
Address
The Coliseum Riverside Way, Watchmoor Park
GU15 3YL Camberley
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
ANTIBODIES FOR RESEARCH APPLICATIONS BV
Netherlands
EU contribution
€ 54 000
Address
Leenmanslag 57
2805 HT Gouda
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
TECOBIOSCIENCES GMBH
Germany
EU contribution
€ 108 000
Address
Bussardstrasse 35
84036 Landshut
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM
Netherlands
EU contribution
€ 54 000
Address
Dr Molewaterplein 40
3015 GD Rotterdam
Activity type
Higher or Secondary Education Establishments
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
Germany
EU contribution
€ 108 000
Address
Hofgartenstrasse 8
80539 Munchen
Activity type
Research Organisations