Understanding and exploiting the insect P450 resistome

Project Information

P450RESIST

Grant agreement ID: 646625

DOI 10.3030/646625

Project closed

EC signature date 4 December 2015

Start date 1 January 2016

End date 31 December 2021

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 1 975 512,00

EU contribution € 1 975 512,00

Coordinated by

THE UNIVERSITY OF EXETER
United Kingdom

Publications

Peer reviewed articles (14)

Evolution of Mutator transposable elements across eukaryotic diversity

Author(s): Dupeyron, Mathilde; Singh, Kumar S.; Bass, Chris; Hayward, Alexander
Published in: Mobile DNA, Issue 32, 2019, ISSN 1759-8753
Publisher: BioMed Central
DOI: 10.1186/s13100-019-0153-8

The evolutionary origins of pesticide resistance

Author(s): Hawkins, Nichola J.; Bass, Chris; Dixon, Andrea; Neve, Paul
Published in: Biological Reviews of the Cambridge Philosophical Society, Issue 12, 2018, ISSN 1464-7931
Publisher: Cambridge University Press
DOI: 10.1111/brv.12440

Transposon-mediated insertional mutagenesis unmasks recessive insecticide resistance in the aphid Myzus persicae

Author(s): Michela Panini, Olga Chiesa, Bartlomiej J. Troczka, Mark Mallott, Gian Carlo Manicardi, Stefano Cassanelli, Filippo Cominelli, Alex Hayward, Emanuele Mazzoni, Chris Bass
Published in: Proceedings of the National Academy of Sciences, 2021, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.2100559118

Genomic insights into neonicotinoid sensitivity in the solitary bee Osmia bicornis

Author(s): Katherine Beadle, Kumar Saurabh Singh, Bartlomiej J. Troczka, Emma Randall, Marion Zaworra, Christoph T. Zimmer, Angela Hayward, Rebecca Reid, Laura Kor, Maxie Kohler, Benjamin Buer, David R. Nelson, Martin S. Williamson, T. G. Emyr Davies, Linda M. Field, Ralf Nauen, Chris Bass
Published in: Plos Genetics, 2019, ISSN 1553-7390
Publisher: Public Library of Science
DOI: 10.1371/journal.pgen.1007903

Identification and functional characterisation of a novel N-cyanoamidine neonicotinoid metabolising cytochrome P450, CYP9Q6, from the buff-tailed bumblebee Bombus terrestris.

Author(s): Bartlomiej J. Troczka; Bartlomiej J. Troczka; Rafael A. Homem; Rebecca Reid; Katherine Beadle; Maxie Kohler; Marion Zaworra; Linda M. Field; Martin S. Williamson; Ralf Nauen; Chris Bass; T.G. Emyr Davies
Published in: Insect Biochemistry and Molecular Biology, Issue 3, 2019, ISSN 0965-1748
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.ibmb.2019.05.006

The leafcutter bee, Megachile rotundata, is more sensitive to N-cyanoamidine neonicotinoid and butenolide insecticides than other managed bees

Author(s): Angela Hayward, Katherine Beadle, Kumar Saurabh Singh, Nina Exeler, Marion Zaworra, Maria-Teresa Almanza, Alexander Nikolakis, Christina Garside, Johannes Glaubitz, Chris Bass, Ralf Nauen
Published in: Nature Ecology and Evolution, 2019, ISSN 2397-334X
Publisher: Springer, Nature
DOI: 10.1038/s41559-019-1011-2

Molecular innovations underlying resistance to nicotine and neonicotinoids in the aphid Myzus persicae

Author(s): Bartlomiej J Troczka, Kumar Saurabh Singh, Christoph T Zimmer, John Vontas, Ralf Nauen, Alex Hayward, Chris Bass
Published in: Pest Management Science, 2021, ISSN 1526-4998
Publisher: Wiley
DOI: 10.1002/ps.6558

Fly-Tox: A panel of transgenic flies expressing pest and pollinator cytochrome P450s

Author(s): Amy McLeman, Bartlomiej J. Troczka, Rafael A. Homem, Ana Duarte, Christoph Zimmer, William T. Garrood, Adam Pym, Katherine Beadle, Rebecca J. Reid, Vassilis Douris, John Vontas, T. G. Emyr Davies, Richard ffrench-Constant, Ralf Nauen, Chris Bass
Published in: Pesticide Biochemistry and Physiology, 2020, ISSN 0048-3575
Publisher: Academic Press
DOI: 10.1016/j.pestbp.2020.104674

Does host plant adaptation lead to pesticide resistance in generalist herbivores

Author(s): Wannes Dermauw; Adam Pym; Chris Bass; Thomas Van Leeuwen; René Feyereisen; René Feyereisen
Published in: Current Opinion in Insect Science, Issue 2, 2018, ISSN 2214-5745
Publisher: Elsevier BV
DOI: 10.1016/j.cois.2018.01.001

Unravelling the Molecular Determinants of Bee Sensitivity to Neonicotinoid Insecticides

Author(s): Cristina Manjon, Bartlomiej J. Troczka, Marion Zaworra, Katherine Beadle, Emma Randall, Gillian Hertlein, Kumar Saurabh Singh, Christoph T. Zimmer, Rafael A. Homem, Bettina Lueke, Rebecca Reid, Laura Kor, Maxie Kohler, Jürgen Benting, Martin S. Williamson, T.G. Emyr Davies, Linda M. Field, Chris Bass, Ralf Nauen
Published in: Current Biology, Issue 28/7, 2018, Page(s) 1137-1143.e5, ISSN 0960-9822
Publisher: Cell Press
DOI: 10.1016/j.cub.2018.02.045

Neofunctionalization of Duplicated P450 Genes Drives the Evolution of Insecticide Resistance in the Brown Planthopper

Author(s): Christoph T. Zimmer, William T. Garrood, Kumar Saurabh Singh, Emma Randall, Bettina Lueke, Oliver Gutbrod, Svend Matthiesen, Maxie Kohler, Ralf Nauen, T.G. Emyr Davies, Chris Bass
Published in: Current Biology, Issue 28/2, 2018, Page(s) 268-274.e5, ISSN 0960-9822
Publisher: Cell Press
DOI: 10.1016/j.cub.2017.11.060

The genetic architecture of a host shift: An adaptive walk protected an aphid and its endosymbiont from plant chemical defenses

Author(s): Kumar Saurabh Singh, Bartlomiej J. Troczka, Ana Duarte, Vasileia Balabanidou, Nasser Trissi, Leonela Z. Carabajal Paladino, Petr Nguyen, Christoph T. Zimmer, Kyriaki M. Papapostolou, Emma Randall, Bettina Lueke, Frantisek Marec, Emanuele Mazzoni, Martin S. Williamson, Alex Hayward, Ralf Nauen, John Vontas, Chris Bass
Published in: Science Advances, Issue 6/19, 2020, Page(s) eaba1070, ISSN 2375-2548
Publisher: American Association for the Advancement of Science
DOI: 10.1126/sciadv.aba1070

Phylogenetic analysis of the Tc1/mariner superfamily reveals the unexplored diversity of pogo-like elements.

Author(s): Mathilde Dupeyron; Tobias Baril; Chris Bass; Alexander Hayward
Published in: Mobile DNA, Issue 1, 2020, ISSN 1759-8753
Publisher: BioMed Central
DOI: 10.1186/s13100-020-00212-0

Global patterns in genomic diversity underpinning the evolution of insecticide resistance in the aphid crop pest Myzus persicae

Author(s): Kumar Saurabh Singh, Erick M. G. Cordeiro, Bartlomiej J. Troczka, Adam Pym, Joanna Mackisack, Thomas C. Mathers, Ana Duarte, Fabrice Legeai, Stéphanie Robin, Pablo Bielza, Hannah J. Burrack, Kamel Charaabi, Ian Denholm, Christian C. Figueroa, Richard H. ffrench-Constant, Georg Jander, John T. Margaritopoulos, Emanuele Mazzoni, Ralf Nauen, Claudio C. Ramírez, Guangwei Ren, Ilona Stepanyan, Paul A
Published in: Communications Biology, 2021, ISSN 2399-3642
Publisher: Springer, Nature
DOI: 10.1038/s42003-021-02373-x