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Translating Hybrid Imaging for Interventions: Intra-operative Guidance and Evaluation using 2D and 3D Interventional X-ray Scintigraphy Imaging

Objective

I propose to research, build and evaluate Interventional X-ray and Scintigraphy Imaging (IXSI). This will provide for the first time real-time, multimodality imaging during medical interventions by combining live x-ray and live nuclear imaging simultaneously from an identical viewpoint. The hybrid x-ray/nuclear imaging device will enable surgeons and interventional radiologists to exploit the power of molecular imaging in the operating theatre and intervention room through i) live guidance using 2D imaging and ii) 3D quantitative evaluation (IXSI3D). Systems, like the successful PET/CT and SPECT/CT, have revolutionized diagnostic medical imaging; however they acquire x-ray (anatomical information) and nuclear images (molecular information) in sequence. Our new technology brings live, hybrid imaging to operations and interventions. This will have a broad and powerful impact, particularly in oncological applications, including internal radiotherapy, tumor resection and biopsies.
For combined X-ray/nuclear imaging, an x-ray tube, an x-ray detector and a gamma camera with collimator are required. Our concept relies on placing these three elements in one line, thus enabling imaging of the same field-of-view. However, straight-forward combination of these elements would block the line of views. Inspired by how eyes see around the nose, I invented a gamma camera geometry that sees around the x-ray tube. I have created a prototype, and using a provisional set-up based on this novel concept (patent pending), I have demonstrated IXSI’s basic principles. This proposal describes the quantum leap in medical imaging: clinical realization of IXSI for guidance, and the development of IXSI3D that enables intra-operative quantitative evaluation. I will develop algorithms and hardware, build a mobile system and prove it’s potential in a clinical research protocol. This will be the start of a new era in image-guided intervention.

Field of science

  • /engineering and technology/electrical engineering, electronic engineering, information engineering/electronic engineering/sensors/optical sensors
  • /agricultural sciences/animal and dairy science/pets
  • /humanities/arts/performing arts/dramaturgy
  • /natural sciences/physical sciences/theoretical physics/particle physics/photons
  • /medical and health sciences/clinical medicine/surgery
  • /engineering and technology/medical engineering/diagnostic imaging
  • /medical and health sciences/clinical medicine/radiology
  • /medical and health sciences/clinical medicine/cancer/breast cancer
  • /natural sciences/mathematics/pure mathematics/geometry
  • /medical and health sciences/clinical medicine/cancer/liver cancer

Call for proposal

ERC-2014-CoG
See other projects for this call

Funding Scheme

ERC-COG - Consolidator Grant

Host institution

UNIVERSITAIR MEDISCH CENTRUM UTRECHT
Address
Heidelberglaan 100
3584 CX Utrecht
Netherlands
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 1 999 000

Beneficiaries (1)

UNIVERSITAIR MEDISCH CENTRUM UTRECHT
Netherlands
EU contribution
€ 1 999 000
Address
Heidelberglaan 100
3584 CX Utrecht
Activity type
Higher or Secondary Education Establishments