Chromatin function in DNA Double Strand breaks repair: Prime, repair and restore DSB Inducible via AsiSI

Project Information

DIvA

Grant agreement ID: 647344

DOI 10.3030/647344

Project closed

EC signature date 23 April 2015

Start date 1 July 2015

End date 31 December 2020

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 2 000 000,00

EU contribution € 2 000 000,00

Coordinated by

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
France

Publications

Peer reviewed articles (15)

The Secret Life of Chromosome Loops upon DNA Double-Strand Break

Author(s): Coline Arnould, Gaëlle Legube
Published in: Journal of Molecular Biology, Issue 432/3, 2020, Page(s) 724-736, ISSN 0022-2836
Publisher: Academic Press
DOI: 10.1016/j.jmb.2019.07.036

A cohesin/HUSH- and LINC-dependent pathway controls ribosomal DNA double-strand break repair

Author(s): Aline Marnef, Anne-Laure Finoux, Coline Arnould, Emmanuelle Guillou, Virginie Daburon, Vincent Rocher, Thomas Mangeat, Philippe E. Mangeot, Emiliano P. Ricci, Gaëlle Legube
Published in: Genes & Development, Issue 33/17-18, 2019, Page(s) 1175-1190, ISSN 0890-9369
Publisher: Cold Spring Harbor Laboratory Press
DOI: 10.1101/gad.324012.119

A Snapshot on the Cis Chromatin Response to DNA Double-Strand Breaks

Author(s): Thomas Clouaire, Gaëlle Legube
Published in: Trends in Genetics, Issue 35/5, 2019, Page(s) 330-345, ISSN 0168-9525
Publisher: Elsevier BV
DOI: 10.1016/j.tig.2019.02.003

Comprehensive Mapping of Histone Modifications at DNA Double-Strand Breaks Deciphers Repair Pathway Chromatin Signatures

Author(s): Thomas Clouaire, Vincent Rocher, Anahita Lashgari, Coline Arnould, Marion Aguirrebengoa, Anna Biernacka, Magdalena Skrzypczak, François Aymard, Bernard Fongang, Norbert Dojer, Jason S. Iacovoni, Maga Rowicka, Krzysztof Ginalski, Jacques Côté, Gaëlle Legube
Published in: Molecular Cell, Issue 72/2, 2018, Page(s) 250-262.e6, ISSN 1097-2765
Publisher: Cell Press
DOI: 10.1016/j.molcel.2018.08.020

Organizing DNA repair in the nucleus: DSBs hit the road

Author(s): Aline Marnef, Gaëlle Legube
Published in: Current Opinion in Cell Biology, Issue 46, 2017, Page(s) 1-8, ISSN 0955-0674
Publisher: Elsevier BV
DOI: 10.1016/j.ceb.2016.12.003

Histone demethylase KDM5A regulates the ZMYND8–NuRD chromatin remodeler to promote DNA repair

Author(s): Fade Gong, Thomas Clouaire, Marion Aguirrebengoa, Gaëlle Legube, Kyle M. Miller
Published in: The Journal of Cell Biology, Issue 216/7, 2017, Page(s) 1959-1974, ISSN 0021-9525
Publisher: Rockefeller University Press
DOI: 10.1083/jcb.201611135

Transcription-Coupled DNA Double-Strand Break Repair: Active Genes Need Special Care

Author(s): Aline Marnef, Sarah Cohen, Gaëlle Legube
Published in: Journal of Molecular Biology, Issue 429/9, 2017, Page(s) 1277-1288, ISSN 0022-2836
Publisher: Academic Press
DOI: 10.1016/j.jmb.2017.03.024

A meeting at risk: Unrepaired DSBs go for broke

Author(s): Aude Guénolé, Gaëlle Legube
Published in: Nucleus, Issue 8/6, 2017, Page(s) 589-599, ISSN 1949-1034
Publisher: Landes Bioscience
DOI: 10.1080/19491034.2017.1380138

Genome-wide mapping of long-range contacts unveils clustering of DNA double-strand breaks at damaged active genes

Author(s): François Aymard, Marion Aguirrebengoa, Emmanuelle Guillou, Biola M Javierre, Beatrix Bugler, Coline Arnould, Vincent Rocher, Jason S Iacovoni, Anna Biernacka, Magdalena Skrzypczak, Krzysztof Ginalski, Maga Rowicka, Peter Fraser, Gaëlle Legube
Published in: Nature Structural & Molecular Biology, Issue 24/4, 2017, Page(s) 353-361, ISSN 1545-9993
Publisher: Nature Publishing Group
DOI: 10.1038/nsmb.3387

Taming Tricky DSBs: ATM on duty

Author(s): Thomas Clouaire, Aline Marnef, Gaëlle Legube
Published in: DNA Repair, Issue 56, 2017, Page(s) 84-91, ISSN 1568-7864
Publisher: Elsevier BV
DOI: 10.1016/j.dnarep.2017.06.010

The TIP60 Complex Regulates Bivalent Chromatin Recognition by 53BP1 through Direct H4K20me Binding and H2AK15 Acetylation

Author(s): Karine Jacquet, Amélie Fradet-Turcotte, Nikita Avvakumov, Jean-Philippe Lambert, Céline Roques, Raj K. Pandita, Eric Paquet, Pauline Herst, Anne-Claude Gingras, Tej K. Pandita, Gaëlle Legube, Yannick Doyon, Daniel Durocher, Jacques Côté
Published in: Molecular Cell, Issue 62/3, 2016, Page(s) 409-421, ISSN 1097-2765
Publisher: Cell Press
DOI: 10.1016/j.molcel.2016.03.031

Non-redundant Functions of ATM and DNA-PKcs in Response to DNA Double-Strand Breaks

Author(s): Pierre Caron, Jonathan Choudjaye, Thomas Clouaire, Béatrix Bugler, Virginie Daburon, Marion Aguirrebengoa, Thomas Mangeat, Jason S. Iacovoni, Alejandro Álvarez-Quilón, Felipe Cortés-Ledesma, Gaëlle Legube
Published in: Cell Reports, Issue 13/8, 2015, Page(s) 1598-1609, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2015.10.024

Senataxin resolves RNA:DNA hybrids forming at DNA double-strand breaks to prevent translocations

Author(s): Sarah Cohen, Nadine Puget, Yea-Lih Lin, Thomas Clouaire, Marion Aguirrebengoa, Vincent Rocher, Philippe Pasero, Yvan Canitrot, Gaëlle Legube
Published in: Nature Communications, Issue 9/1, 2018, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-018-02894-w

Predicting double-strand DNA breaks using epigenome marks or DNA at kilobase resolution

Author(s): Raphaël Mourad, Krzysztof Ginalski, Gaëlle Legube, Olivier Cuvier
Published in: Genome Biology, Issue 19/1, 2018, ISSN 1474-760X
Publisher: Springer Nature
DOI: 10.1186/s13059-018-1411-7

Non-canonical DNA/RNA structures during Transcription-Coupled Double-Strand Break Repair: Roadblocks or Bona fide repair intermediates?

Author(s): Nadine Puget, Kyle M. Miller, Gaëlle Legube
Published in: DNA Repair, Issue 81, 2019, Page(s) 102661, ISSN 1568-7864
Publisher: Elsevier BV
DOI: 10.1016/j.dnarep.2019.102661

Non-peer reviewed articles (1)

A TAD closer to ATM

Author(s): Francois Aymard, Gaëlle Legube
Published in: Molecular & Cellular Oncology, Issue 3/3, 2015, Page(s) e1134411, ISSN 2372-3556
Publisher: Taylor & Francis, Inc.
DOI: 10.1080/23723556.2015.1134411