In-cell NMR monitoring of alpha-Synuclein aggregation in neuronal cells

Project Information

NeuroInCellNMR

Grant agreement ID: 647474

DOI 10.3030/647474

Project closed

EC signature date 13 May 2015

Start date 1 November 2015

End date 31 October 2022

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 1 996 500,00

EU contribution € 1 996 500,00

Coordinated by

WEIZMANN INSTITUTE OF SCIENCE
Israel

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (15)

Cells, drugs and NMR

Author(s): Gregg Siegal, Philipp Selenko
Published in: Journal of Magnetic Resonance, Issue 306, 2019, Page(s) 202, ISSN 1090-7807
Publisher: Academic Press
DOI: 10.1016/j.jmr.2019.07.018

Mechanical stress impairs pheromone signaling via Pkc1-mediated regulation of the MAPK scaffold Ste5.

Author(s): Frank van Drogen, Ranjan Mishra, Fabian Rudolf, Michal J Walczak, Sung Sik Lee, Wolfgang Reiter, Björn Hegemann, Serge Pelet, Ilse Dohnal, Andres Binolfi, Zinaida Yudina, Philipp Selenko, Gerhard Wider, Gustav Ammerer, Matthias Peter
Published in: Journal of Cell Biology, Issue 218/9, 2019, Page(s) 3117, ISSN 0021-9525
Publisher: Rockefeller University Press
DOI: 10.1083/jcb.201808161

Electroporated recombinant proteins as tools for in vivo functional complementation, imaging and chemical biology

Author(s): Amal Alex; Valentina Piano; Soumitra Polley; Marchel Stuiver; Marchel Stuiver; Stephanie Voss; Giuseppe Ciossani; Katharina Overlack; Beate Voss; Sabine Wohlgemuth; Arsen Petrovic; Arsen Petrovic; Yao-Wen Wu; Yao-Wen Wu; Philipp Selenko; Philipp Selenko; Andrea Musacchio; Andrea Musacchio; Stefano Maffini
Published in: eLife, Issue 8/e48287, 2019, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.48287

An NMR-Based Biosensor to Measure Stereospecific Methionine Sulfoxide Reductase Activities in Vitro and in Vivo.

Author(s): Carolina Snchez-Lpez, Natalia Labadie, Vernica A Lombardo, Franco A Biglione, Bruno Manta, Reeba Susan Jacob, Vadim N Gladyshev, Salim Abdelilah-Seyfried, Philipp Selenko, Andres Binolfi
Published in: Chemistry, Issue 26/65, 2020, Page(s) 14838, ISSN 0947-6539
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/chem.202002645

Quantitative mass imaging of single molecules in solution

Author(s): Gavin Young; Nikolas Hundt; Daniel Cole; Adam Fineberg; Joanna Andrecka; Andrew Tyler; Anna Olerinyova; A Ansari; Erik G. Marklund; Miranda P. Collier; Shane A. Chandler; Olga Tkachenko; Joel D. Allen; Max Crispin; Neil Billington; Yasuharu Takagi; James R. Sellers; Cédric Eichmann; Philipp Selenko; Lukas Frey; Roland Riek; Martin R. Galpin; Weston B. Struwe; Justin L. P. Benesch; Philipp Kukura
Published in: Science, Issue 360/6387, 2018, Page(s) 423, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1101/229740

Quantitative mass imaging of single biological macromolecules

Author(s): Gavin Young, Nikolas Hundt, Daniel Cole, Adam Fineberg, Joanna Andrecka, Andrew Tyler, Anna Olerinyova, Ayla Ansari, Erik G. Marklund, Miranda P. Collier, Shane A. Chandler, Olga Tkachenko, Joel Allen, Max Crispin, Neil Billington, Yasuharu Takagi, James R. Sellers, Cédric Eichmann, Philipp Selenko, Lukas Frey, Roland Riek, Martin R. Galpin, Weston B. Struwe, Justin L. P. Benesch, Philipp Kukura
Published in: Science, Issue 360/6387, 2018, Page(s) 423-427, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.aar5839

Structural Biology outside the box — inside the cell

Author(s): Jürgen M Plitzko, Benjamin Schuler, Philipp Selenko
Published in: Current Opinion in Structural Biology, Issue 46, 2017, Page(s) 110-121, ISSN 0959-440X
Publisher: Elsevier BV
DOI: 10.1016/j.sbi.2017.06.007

Structural disorder of monomeric α-synuclein persists in mammalian cells

Author(s): Francois-Xavier Theillet, Andres Binolfi, Beata Bekei, Andrea Martorana, Honor May Rose, Marchel Stuiver, Silvia Verzini, Dorothea Lorenz, Marleen van Rossum, Daniella Goldfarb, Philipp Selenko
Published in: Nature, Issue 530/7588, 2016, Page(s) 45-50, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/nature16531

Opposing effects of Elk-1 multisite phosphorylation shape its response to ERK activation

Author(s): A. Mylona, F.-X. Theillet, C. Foster, T. M. Cheng, F. Miralles, P. A. Bates, P. Selenko, R. Treisman
Published in: Science, Issue 354/6309, 2016, Page(s) 233-237, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.aad1872

Intracellular repair of oxidation-damaged α-synuclein fails to target C-terminal modification sites

Author(s): Andres Binolfi, Antonio Limatola, Silvia Verzini, Jonas Kosten, Francois-Xavier Theillet, Honor May Rose, Beata Bekei, Marchel Stuiver, Marleen van Rossum, Philipp Selenko
Published in: Nature Communications, Issue 7, 2016, Page(s) 10251, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/ncomms10251

In-Cell Protein Structures from 2D NMR Experiments

Author(s): Thomas Müntener, Daniel Häussinger, Philipp Selenko, Francois-Xavier Theillet
Published in: The Journal of Physical Chemistry Letters, Issue 7/14, 2016, Page(s) 2821-2825, ISSN 1948-7185
Publisher: American Chemical Society
DOI: 10.1021/acs.jpclett.6b01074

-Synuclein plasma membrane localization correlates with cellular phosphatidylinositol polyphosphate levels

Author(s): Reeba Susan Jacob; Cdric Eichmann; Alessandro Dema; Davide Mercadante; Philipp Selenko
Published in: eLife, Issue 10/e61951, 2021, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.1101/2020.07.31.224600

Time-Resolved NMR Analysis of Proteolytic α-Synuclein Processing in vitro and in cellulo.

Author(s): Antonio Limatola, Cédric Eichmann, Reeba Susan Jacob, Gili Ben-Nissan, Michal Sharon, Andres Binolfi, Philipp Selenko
Published in: Proteomics, Issue 432/166689, 2018, ISSN 1615-9853
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/pmic.201800056

Megadalton-sized Dityrosine Aggregates of -Synuclein Retain High Degrees of Structural Disorder and Internal Dynamics.

Author(s): Silvia Verzini; Maliah Shah; Francois-Xavier Theillet; Adam Belsom; Jan Bieschke; Erich E. Wanker; Juri Rappsilber; Andres Binolfi; Philipp Selenko
Published in: Journal of Molecular Biology, Issue 432/24, 2020, Page(s) 166689, ISSN 0022-2836
Publisher: Academic Press
DOI: 10.1016/j.jmb.2020.10.023

Quo Vadis Biomolecular NMR Spectroscopy

Author(s): Philipp Selenko
Published in: International Journal of Molecular Sciences, Issue 20/6, 2019, Page(s) 1278, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms20061278