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The Unfolded Protein Response in Neurodegeneration


Neuronal Mitochondrial Dysfunction Activates the Integrated Stress Response to Induce Fibroblast Growth Factor 21

Author(s): Lisa Michelle Restelli, Björn Oettinghaus, Mark Halliday, Cavit Agca, Maria Licci, Lara Sironi, Claudia Savoia, Jürgen Hench, Markus Tolnay, Albert Neutzner, Alexander Schmidt, Anne Eckert, Giovanna Mallucci, Luca Scorrano, Stephan Frank
Published in: Cell Reports, Issue 24/6, 2018, Page(s) 1407-1414, ISSN 2211-1247
DOI: 10.1016/j.celrep.2018.07.023

M1 muscarinic allosteric modulators slow prion neurodegeneration and restore memory loss

Author(s): Sophie J. Bradley, Julie-Myrtille Bourgognon, Helen E. Sanger, Nicholas Verity, Adrian J. Mogg, David J. White, Adrian J. Butcher, Julie A. Moreno, Colin Molloy, Timothy Macedo-Hatch, Jennifer M. Edwards, Jurgen Wess, Robert Pawlak, David J. Read, Patrick M. Sexton, Lisa M. Broad, Joern R. Steinert, Giovanna R. Mallucci, Arthur Christopoulos, Christian C. Felder, Andrew B. Tobin
Published in: Journal of Clinical Investigation, Issue 127/2, 2017, Page(s) 487-499, ISSN 0021-9738
DOI: 10.1172/JCI87526

Astrocyte Unfolded Protein Response Induces a Specific Reactivity State that Causes Non-Cell-Autonomous Neuronal Degeneration

Author(s): Heather L. Smith, Oliver J. Freeman, Adrian J. Butcher, Staffan Holmqvist, Ibrahim Humoud, Tobias Schätzl, Daniel T. Hughes, Nicholas C. Verity, Dean P. Swinden, Joseph Hayes, Lis de Weerd, David H. Rowitch, Robin J.M. Franklin, Giovanna R. Mallucci
Published in: Neuron, Issue 105/5, 2020, Page(s) 855-866.e5, ISSN 0896-6273
DOI: 10.1016/j.neuron.2019.12.014

Noncanonical Modulation of the eIF2 Pathway Controls an Increase in Local Translation during Neural Wiring

Author(s): Roberta Cagnetta, Hovy Ho-Wai Wong, Christian K. Frese, Giovanna R. Mallucci, Jeroen Krijgsveld, Christine E. Holt
Published in: Molecular Cell, Issue 73/3, 2019, Page(s) 474-489.e5, ISSN 1097-2765
DOI: 10.1016/j.molcel.2018.11.013

The UPR and synaptic dysfunction in neurodegeneration

Author(s): Oliver J. Freeman, Giovanna R. Mallucci
Published in: Brain Research, Issue 1648, 2016, Page(s) 530-537, ISSN 0006-8993
DOI: 10.1016/j.brainres.2016.03.029

Repurposed drugs targeting eIF2α-P-mediated translational repression prevent neurodegeneration in mice

Author(s): Mark Halliday, Helois Radford, Karlijn A. M. Zents, Collin Molloy, Julie A. Moreno, Nicholas C. Verity, Ewan Smith, Catharine A. Ortori, David A. Barrett, Martin Bushell, Giovanna R. Mallucci
Published in: Brain, Issue 140/6, 2017, Page(s) 1768-1783, ISSN 0006-8950
DOI: 10.1093/brain/awx074

The unfolded protein response: mechanisms and therapy of neurodegeneration

Author(s): Heather L. Smith, Giovanna R. Mallucci
Published in: Brain, Issue 139/8, 2016, Page(s) 2113-2121, ISSN 0006-8950
DOI: 10.1093/brain/aww101

Mitofusin-mediated ER stress triggers neurodegeneration in pink1/parkin models of Parkinson’s disease

Author(s): I Celardo, A C Costa, S Lehmann, C Jones, N Wood, N E Mencacci, G R Mallucci, S H Y Loh, L M Martins
Published in: Cell Death and Disease, Issue 7/6, 2016, Page(s) e2271, ISSN 2041-4889
DOI: 10.1038/cddis.2016.173

Fine-tuning PERK signaling for neuroprotection

Author(s): Mark Halliday, Daniel Hughes, Giovanna R. Mallucci
Published in: Journal of Neurochemistry, Issue 142/6, 2017, Page(s) 812-826, ISSN 0022-3042
DOI: 10.1111/jnc.14112

Translating translation in Down syndrome

Author(s): Mark Halliday, Giovanna R. Mallucci
Published in: Science, Issue 366/6467, 2019, Page(s) 797-798, ISSN 0036-8075
DOI: 10.1126/science.aaz7128