The Unfolded Protein Response in Neurodegeneration

Project Information

UPR NEURO

Grant agreement ID: 647479

DOI 10.3030/647479

Project closed

EC signature date 31 July 2015

Start date 1 September 2015

End date 28 February 2021

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 1 979 286,00

EU contribution € 1 979 286,00

Coordinated by

THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
United Kingdom

Publications

Peer reviewed articles (10)

The unfolded protein response in neurodegenerative disorders - therapeutic modulation of the PERK pathway

Author(s): Daniel Hughes, Giovanna R. Mallucci
Published in: The FEBS Journal, Issue 286/2, 2019, Page(s) 342-355, ISSN 1742-464X
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/febs.14422

Developing Therapies for Neurodegenerative Disorders: Insights from Protein Aggregation and Cellular Stress Responses

Author(s): Giovanna R. Mallucci, David Klenerman, David C. Rubinsztein
Published in: Annual Review of Cell and Developmental Biology, Issue 36/1, 2020, Page(s) 165-189, ISSN 1081-0706
Publisher: Annual Reviews, Inc.
DOI: 10.1146/annurev-cellbio-040320-120625

Neuronal Mitochondrial Dysfunction Activates the Integrated Stress Response to Induce Fibroblast Growth Factor 21

Author(s): Lisa Michelle Restelli, Björn Oettinghaus, Mark Halliday, Cavit Agca, Maria Licci, Lara Sironi, Claudia Savoia, Jürgen Hench, Markus Tolnay, Albert Neutzner, Alexander Schmidt, Anne Eckert, Giovanna Mallucci, Luca Scorrano, Stephan Frank
Published in: Cell Reports, Issue 24/6, 2018, Page(s) 1407-1414, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2018.07.023

Astrocyte Unfolded Protein Response Induces a Specific Reactivity State that Causes Non-Cell-Autonomous Neuronal Degeneration

Author(s): Heather L. Smith, Oliver J. Freeman, Adrian J. Butcher, Staffan Holmqvist, Ibrahim Humoud, Tobias Schätzl, Daniel T. Hughes, Nicholas C. Verity, Dean P. Swinden, Joseph Hayes, Lis de Weerd, David H. Rowitch, Robin J.M. Franklin, Giovanna R. Mallucci
Published in: Neuron, Issue 105/5, 2020, Page(s) 855-866.e5, ISSN 0896-6273
Publisher: Cell Press
DOI: 10.1016/j.neuron.2019.12.014

Noncanonical Modulation of the eIF2 Pathway Controls an Increase in Local Translation during Neural Wiring

Author(s): Roberta Cagnetta, Hovy Ho-Wai Wong, Christian K. Frese, Giovanna R. Mallucci, Jeroen Krijgsveld, Christine E. Holt
Published in: Molecular Cell, Issue 73/3, 2019, Page(s) 474-489.e5, ISSN 1097-2765
Publisher: Cell Press
DOI: 10.1016/j.molcel.2018.11.013

The UPR and synaptic dysfunction in neurodegeneration

Author(s): Oliver J. Freeman, Giovanna R. Mallucci
Published in: Brain Research, Issue 1648, 2016, Page(s) 530-537, ISSN 0006-8993
Publisher: Elsevier BV
DOI: 10.1016/j.brainres.2016.03.029

Repurposed drugs targeting eIF2α-P-mediated translational repression prevent neurodegeneration in mice

Author(s): Mark Halliday, Helois Radford, Karlijn A. M. Zents, Collin Molloy, Julie A. Moreno, Nicholas C. Verity, Ewan Smith, Catharine A. Ortori, David A. Barrett, Martin Bushell, Giovanna R. Mallucci
Published in: Brain, Issue 140/6, 2017, Page(s) 1768-1783, ISSN 0006-8950
Publisher: Oxford University Press
DOI: 10.1093/brain/awx074

The unfolded protein response: mechanisms and therapy of neurodegeneration

Author(s): Heather L. Smith, Giovanna R. Mallucci
Published in: Brain, Issue 139/8, 2016, Page(s) 2113-2121, ISSN 0006-8950
Publisher: Oxford University Press
DOI: 10.1093/brain/aww101

Fine-tuning PERK signaling for neuroprotection

Author(s): Mark Halliday, Daniel Hughes, Giovanna R. Mallucci
Published in: Journal of Neurochemistry, Issue 142/6, 2017, Page(s) 812-826, ISSN 0022-3042
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/jnc.14112

Targeting the kinase insert loop of PERK selectively modulates PERK signaling without systemic toxicity in mice

Author(s): Daniel T. Hughes, Mark Halliday, Heather L. Smith, Nicholas C. Verity, Colin Molloy, Helois Radford, Adrian J. Butcher, Giovanna R. Mallucci
Published in: Science Signaling, Issue 13/644, 2020, ISSN 1937-9145
Publisher: American Association for the Advancement of Science
DOI: 10.1126/scisignal.abb4749

Non-peer reviewed articles (2)

Translating translation in Down syndrome

Author(s): Mark Halliday, Giovanna R. Mallucci
Published in: Science, Issue 366/6467, 2019, Page(s) 797-798, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.aaz7128

Small Molecules to Improve ER Proteostasis in Disease

Author(s): Vicente Gonzalez-Teuber, Hector Albert-Gasco, Vincent C. Auyeung, Feroz R. Papa, Giovanna R. Mallucci, Claudio Hetz
Published in: Trends in Pharmacological Sciences, Issue 40/9, 2019, Page(s) 684-695, ISSN 0165-6147
Publisher: Elsevier BV
DOI: 10.1016/j.tips.2019.07.003