Objective Micro-organisms were believed until recently to live independent, unicellular lives but are now understood to rely on complex systems of social behaviours for survival. In pathogenic bacteria, cooperation and communication between cells leads to increased virulence and the understanding of how these behaviours evolve is of fundamental importance to the future of human health. Almost nothing is known, however, about social behaviours of bacteria infecting human hosts, and research on social behaviour in microbes is limited to well-characterised lab strains. This proposal describes a program of research designed to exploit the opportunities offered by an interdisciplinary approach to address the growing challenge posed to human health by disease caused by bacterial infection. Specifically, I have three primary objectives: (1) to develop a model system for investigating social behaviour in long-term bacterial infections; (2) to identify evolutionary mechanisms driving dynamics of social behaviour in long-term infections and (3) to exploit social dynamics in the treatment of bacterial infection. This proposal applies evolutionary theory to the clinical challenge of bacterial infection to develop novel intervention strategies beyond the scope of conventional medicine, which is based primarily on understanding of bacteria at the cellular level. Fields of science natural sciencesbiological sciencesmicrobiologybacteriologymedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsantibioticsnatural sciencesbiological sciencesgeneticsgenomesmedical and health sciencesbasic medicinepharmacology and pharmacydrug resistanceantibiotic resistancenatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsenzymes Programme(s) H2020-EU.1.1. - EXCELLENT SCIENCE - European Research Council (ERC) Main Programme Topic(s) ERC-CoG-2014 - ERC Consolidator Grant Call for proposal ERC-2014-CoG See other projects for this call Funding Scheme ERC-COG - Consolidator Grant Coordinator THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD Net EU contribution € 1 954 633,00 Address Wellington square university offices OX1 2JD Oxford United Kingdom See on map Region South East (England) Berkshire, Buckinghamshire and Oxfordshire Oxfordshire Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 Beneficiaries (1) Sort alphabetically Sort by Net EU contribution Expand all Collapse all THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD United Kingdom Net EU contribution € 1 954 633,00 Address Wellington square university offices OX1 2JD Oxford See on map Region South East (England) Berkshire, Buckinghamshire and Oxfordshire Oxfordshire Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00
