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The molecular genetic architecture of educational attainment and its significance for cognitive health

Project description

Using genetics to address educational inequality

Many people around the world suffer from the effects of socio-economic inequality, with access to education being a key factor in determining an individual’s success. While environmental factors play a big role in shaping a student’s academic success, research suggests that genetics may also play a part. However, this complex interplay of genetic and environmental factors has long remained a mystery. In this context, the ERC-funded EdGe project aims to use genetic information to gain insights into the causes and effects of socio economic outcomes, particularly in the realm of educational attainment. Specifically, it will seek to discover genetic variants and other related traits, such as cognitive function and health. The project also hopes to identify individuals at risk for cognition related diseases.

Objective

Since many social and economic outcomes are moderately heritable, it is in principle possible to discover genetic variants associated with them. Such discoveries could yield new insights into the causal pathways underlying human behaviour, the complex interplay of environmental and genetic factors, and the relationship between socio-economic traits and health.
This proposal builds on a recent genome-wide association study on educational attainment (EA) led by the applicant (Rietveld et al. 2013, Science), which identified for the first time specific genetic variants robustly associated with a socio-economic outcome. The project will leverage the unique resources of the Social Science Genetic Association Consortium (SSGAC), which is co-led by the applicant.
The proposed research will extend existing knowledge by: 1) discovering additional genetic variants and causal pathways associated with EA; 2) developing methods to use the available genetic association results in novel, more efficient ways; 3) shedding new light on characteristics related to EA such as economic preferences, cognitive function, and cognitive health; 4) showing how policies promoting EA interact with genetic predisposition; 5) using genetic information to better understand the causal effects of educational policy interventions, 6) developing better tools to identify individuals at risk for cognition-related diseases before the onset of symptoms; and 7) identifying causal pathways of genetic influence on cognitive health via neurobiological measures. The project aims to elucidate the complex causal pathways connecting genes, environment, individual characteristics, and health-related outcomes; make methodological contributions applicable in genetic epidemiology and the social sciences; and contribute towards designing more effective public policy, which could improve public health and lower health costs.

Host institution

STICHTING VU
Net EU contribution
€ 1 870 135,00
Address
DE BOELELAAN 1105
1081 HV Amsterdam
Netherlands

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Region
West-Nederland Noord-Holland Groot-Amsterdam
Activity type
Higher or Secondary Education Establishments
Links
Total cost
€ 1 870 135,00

Beneficiaries (1)