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Water as cosubstrate for biocatalytic redox reactions

Project description

Water as an electron donor to promote oxidoreductases-catalysed transformations

Redox reactions are a central type of conversion in organic synthesis. They involve a transfer of electrons between a donor (which is reduced) and an acceptor (which is oxidised). Oxidoreductases are enzymes that catalyse this transfer. Their activity is usually promoted by stoichiometric cosubstrates such as glucose and alcohols, sacrificing valuable foods as electron donors. Funded by the European Research Council, the BioAqua project will use water instead in a completely novel approach to biocatalysis; it will activate water with visible light and use advanced catalysts to facilitate water oxidation. The liberated electrons will be used to promote oxidoreductases-catalysed transformations in a cleaner and more efficient reaction scheme.

Objective

The research proposed in BioAqua aims at breaking new ground in the area of catalysis by enabling water-driven biocatalytic redox reactions.

Oxidoreductases are a class of enzymes with a very high potential for preparative organic synthesis, which is why they are increasingly used also on industrial scale. The current state-of-the-art, however, utilises valuable high-energy cosubstrates (such as glucose and alcohols) to promote oxidoreductases. Thereby valuable (and edible) building blocks are wasted as sacrificial electron donors which will have significant ethical (food for chemistry), economic and environmental consequences once redox biocatalysis is applied at scale.
I envision utilizing water as sacrificial electron donor. Hence, a simple and abundant cosubstrate will be used instead of the valuable cosubstrates mentioned above. This will be a completely new approach in (bio)catalysis.
However, activating water for this purpose water is extremely difficult due to its kinetic and thermodynamic inertness. To solve this problem, I propose using visible light as external energy source and advanced chemical catalysts to facilitate water oxidation. The electrons liberated in this process will be made available (for the first time) to promote oxidoreductases-catalysed transformations.

BioAqua represents an entirely new paradigm in catalysis as I will bridge the gap between photocatalysis and biocatalysis enabling cleaner and more efficient reaction schemes.

Host institution

TECHNISCHE UNIVERSITEIT DELFT
Net EU contribution
€ 1 998 020,00
Address
STEVINWEG 1
2628 CN Delft
Netherlands

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Region
West-Nederland Zuid-Holland Delft en Westland
Activity type
Higher or Secondary Education Establishments
Links
Total cost
€ 1 998 020,00

Beneficiaries (1)