Description of information transfer across macromolecules by concerted conformational changes

Project Information

CONCERT

Grant agreement ID: 648201

DOI

10.3030/648201

Project closed

EC signature date 11 June 2015

Start date 1 July 2015

End date 30 June 2021

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 950 000,00

EU contribution

€ 1 950 000,00

Coordinated by

FUNDACIO INSTITUT DE RECERCA BIOMEDICA (IRB BARCELONA)
Spain

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (9)

Cancer Mutations of the Tumor Suppressor SPOP Disrupt the Formation of Active, Phase-Separated Compartments

Author(s): Bouchard J. J., Otero J. H., Scott D. C., Szulc E. M., Martin E. W., Sabri N., Granata D., Marzahn M. R., Lindorff-Larsen K., Salvatella X., Schulman B. A., Mittag T.
Published in: Molecular Cell, 2018, Page(s) 19-36, ISSN 1097-2765
Publisher: Cell Press
DOI: 10.1016/j.molcel.2018.08.027

Side chain to main chain hydrogen bonds stabilize a polyglutamine helix in a transcription factor

Author(s): Albert Escobedo, Busra Topal, Micha B. A. Kunze, Juan Aranda, Giulio Chiesa, Daniele Mungianu, Ganeko Bernardo-Seisdedos, Bahareh Eftekharzadeh, Margarida Gairí, Roberta Pierattelli, Isabella C. Felli, Tammo Diercks, Oscar Millet, Jesús García, Modesto Orozco, Ramon Crehuet, Kresten Lindorff-Larsen & Xavier Salvatella
Published in: Nature Communications, 2019, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-019-09923-2

Bayesian-Maximum-Entropy reweighting of IDP ensembles based on NMR chemical shifts

Author(s): Crehuet, Ramon; Buigues, Pedro J.; Salvatella, Xavier; Lindorff-Larsen, Kresten
Published in: Entropy, 2019, ISSN 1099-4300
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/e21090898

Low amounts of heavy water increase the phase separation propensity of a fragment of the androgen receptor activation domain

Author(s): Stasė Bielskutė; Carla Garcia-Cabau; Marta Frigolé-Vivas; Elzbieta Szulc; Eva De Mol; Mireia Pesarrodona; Jesús García; Xavier Salvatella
Published in: Protein Science, 2021, Page(s) 1427-1437, ISSN 1469-896X
Publisher: Wiley
DOI: 10.1002/pro.4110

Hsp70 and Hsp40 inhibit an inter-domain interaction necessary for transcriptional activity in the androgen receptor.

Author(s): Eftekharzadeh, Bahareh; Banduseela, Varuna C.; Chiesa, Giulio; Martínez-Cristóbal, Paula; Rauch, Jennifer N.; Nath, Samir R.; Schwarz, Daniel M. C.; Shao, Hao; Marin-Argany, Marta; Di Sanza, Claudio; Giorgetti, Elisa; Yu, Zhigang; Pierattelli, Roberta; Felli, Isabella C.; Brun-Heath, Isabelle; García, Jesús; Nebreda, Ángel R.; Gestwicki, Jason E.; Lieberman, Andrew P.; Salvatella, Xavier
Published in: Nature Communications, 2019, Page(s) 3562, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-019-11594-y

Development of Bag-1L as a therapeutic target in androgen receptor-dependent prostate cancer

Author(s): Laura Cato, Antje Neeb, Adam Sharp, Victor Buzón, Scott B Ficarro, Linxiao Yang, Claudia Muhle-Goll, Nane C Kuznik, Ruth Riisnaes, Daniel Nava Rodrigues, Olivier Armant, Victor Gourain, Guillaume Adelmant, Emmanuel A Ntim, Thomas Westerling, David Dolling, Pasquale Rescigno, Ines Figueiredo, Friedrich Fauser, Jennifer Wu, Jaice T Rottenberg, Liubov Shatkina, Claudia Ester, Burkhard Luy, Holger Pu
Published in: eLife, Issue 6, 2017, Page(s) e27159, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/eLife.27159

Regulation of Androgen Receptor Activity by Transient Interactions of Its Transactivation Domain with General Transcription Regulators.

Author(s): De Mol E, Szulc E, Di Sanza C, Martínez-Cristóbal P, Bertoncini CW, Fenwick RB, Frigolé-Vivas M, Masín M, Hunter I, Buzón V, Brun-Heath I, García J, De Fabritiis G, Estébanez-Perpiñá E, McEwan IJ, Nebreda ÁR, Salvatella X.
Published in: Structure, 2018, ISSN 0969-2126
Publisher: Cell press
DOI: 10.1016/j.str.2017.11.007

Sequence Context Influences the Structure and Aggregation Behavior of a PolyQ Tract

Author(s): Bahareh Eftekharzadeh, Alessandro Piai, Giulio Chiesa, Daniele Mungianu, Jesús García, Roberta Pierattelli, Isabella C. Felli, Xavier Salvatella
Published in: Biophysical journal, 2016, Page(s) 2361-2366, ISSN 0006-3495
Publisher: Biophysical Society
DOI: 10.1016/j.bpj.2016.04.022

EPI-001, A Compound Active against Castration-Resistant Prostate Cancer, Targets Transactivation Unit 5 of the Androgen Receptor

Author(s): Eva De Mol, R. Bryn Fenwick, Christopher T. W. Phang, Victor Buzón, Elzbieta Szulc, Alex de la Fuente, Albert Escobedo, Jesús García, Carlos W. Bertoncini, Eva Estébanez-Perpiñá, Iain J. McEwan, Antoni Riera, and Xavier Salvatella
Published in: ACS Chemical Biology, 2016, Page(s) 2499-2505, ISSN 1554-8929
Publisher: American Chemical Society
DOI: 10.1021/acschembio.6b00182