Regulation of antibody responses by B cell mechanical activity

Project Information

BCELLMECHANICS

Grant agreement ID: 648228

DOI

10.3030/648228

Project closed

EC signature date 31 July 2015

Start date 1 September 2015

End date 31 May 2022

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 999 386,00

EU contribution

€ 1 999 386,00

Coordinated by

UNIVERSITY COLLEGE LONDON
United Kingdom

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (8)

Digital holography-based 3D particle localisation for single molecule tweezer techniques

Author(s): Flewellen, J. L., Minoughan, S., Garcia, I. L. & Tolar.
Published in: Biophysical Journal, 2022, ISSN 0006-3495
Publisher: Biophysical Society
DOI: 10.1016/j.bpj.2022.06.001

Endophilin A2 regulates B cell protein trafficking and humoral responses

Author(s): Dessislava Malinova; Laabiah Wasim; Niklas Engels; Pavel Tolar
Published in: EMBO Reports, Issue 2, 2021, ISSN 1469-3178
Publisher: EMBO
DOI: 10.1101/2020.04.20.050419

Cytoskeletal control of B cell responses to antigens

Author(s): Pavel Tolar
Published in: Nature Reviews Immunology, Issue 17/10, 2017, Page(s) 621-634, ISSN 1474-1733
Publisher: Nature Publishing Group
DOI: 10.1038/nri.2017.67

Myosin IIa Promotes Antibody Responses by Regulating B Cell Activation, Acquisition of Antigen, and Proliferation

Author(s): Robbert Hoogeboom, Elizabeth M. Natkanski, Carla R. Nowosad, Dessislava Malinova, Rajesh P. Menon, Antonio Casal, Pavel Tolar
Published in: Cell Reports, Issue 23/8, 2018, Page(s) 2342-2353, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2018.04.087

B cell antigen extraction is regulated by physical properties of antigen-presenting cells

Author(s): Spillane KM, Tolar P
Published in: Journal of Cell Biology, 2017, ISSN 0021-9525
Publisher: Rockefeller University Press
DOI: 10.1083/jcb.201607064

Germinal center B cells recognize antigen through a specialized immune synapse architecture

Author(s): Carla R Nowosad, Katelyn M Spillane, Pavel Tolar
Published in: Nature Immunology, Issue 17/7, 2016, Page(s) 870-877, ISSN 1529-2908
Publisher: Nature Publishing Group
DOI: 10.1038/ni.3458

B cells extract antigens at Arp2/3-generated actin foci interspersed with linear filaments

Author(s): Sophie I Roper, Laabiah Wasim, Dessislava Malinova, Michael Way, Susan Cox, Pavel Tolar
Published in: eLife, Issue 8, 2019, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.48093

Intrinsic properties of human germinal center B cells set antigen affinity thresholds

Author(s): Kwak, Kihyuck; Quizon, Nicolas; Sohn, Haewon; Saniee, Avva; Manzella-Lapeira, Javier; Holla, Prasida; Brzostowski, Joseph; Lu, Jinghua; Xie, HengYi; Xu, Chenguang; Spillane, Katelyn M; Tolar, Pavel; Pierce, Susan K
Published in: Science Immunology, 2018, ISSN 2470-9468
Publisher: American Association for the Advancement of Science
DOI: 10.1126/sciimmunol.aau6598

Non-peer reviewed articles (1)

Mechanics of antigen extraction in the B cell synapse.

Author(s): Spillane, Katelyn M.; Tolar, Pavel
Published in: MOLECULAR IMMUNOLOGY, Issue 2, 2018, ISSN 0161-5890
Publisher: Pergamon Press
DOI: 10.1016/j.molimm.2018.07.018

Book chapters (2)

DNA-Based Probes for Measuring Mechanical Forces in Cell-Cell Contacts: Application to B Cell Antigen Extraction from Immune Synapses

Author(s): Katelyn M. Spillane, Pavel Tolar
Published in: Methods in Molecular Biology, 2018, Page(s) 69-80
Publisher: Springer New York
DOI: 10.1007/978-1-4939-7474-0_5

Plasma Membrane Sheets for Studies of B Cell Antigen Internalization from Immune Synapses.

Author(s): Carla R. Nowosad, Pavel Tolar
Published in: Methods in Molecular Biology, 2017, Page(s) 77-88
Publisher: Springer New York
DOI: 10.1007/978-1-4939-6881-7_6